Focal Hepatic Glycogenosis in a Patient with Uncontrolled Diabetes Mellitus Type 1

Tetiana Glushko, Sergiy V. Kushchayev, Dmitry Trifanov, Aliaksei Salei, Diego Morales, Gerard Berry, Justin MacKey, Oleg M. Teytelboym

Research output: Contribution to journalArticlepeer-review


Hepatomegaly and elevated liver enzymes in patients with diabetes are commonly associated with fatty liver disease. However, physicians often forget about another intrinsic substance that can cause a similar clinical picture-glycogen. Liver stores approximately one third of the total body glycogen and is responsible for blood glucose homeostasis. Excessive hepatocellular glycogen accumulation occurs not only in congenital glycogen storage diseases, but also in acquired conditions associated with hyperglycemic-hyperinsulinemic states such as uncontrolled diabetes mellitus, high-dose corticosteroid use, and dumping syndrome. All reported cases of acquired abnormal glycogen deposition described a diffuse form of hepatic glycogenosis with the entire liver involved in the accumulating process. To our knowledge, this is the first reported case of abnormal focal glycogen deposition in a patient with diabetes mellitus type 1 with imaging and pathologic correlation. Awareness of the imaging appearance of focal glycogen deposition can help to distinguish it from other pathologic conditions.

Original languageEnglish (US)
Pages (from-to)230-235
Number of pages6
JournalJournal of computer assisted tomography
Issue number2
StatePublished - Mar 1 2018
Externally publishedYes


  • focal hepatic glycogenosis
  • glycogenic hepatopathy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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