Fluorous synthesis of 18F radiotracers with the [ 18F]fluoride ion: Nucleophilic fluorination as the detagging process

Romain Bejot; Thomas Fowler; Laurence Carroll; Sophie Boldon; Jane E. Moore; Jérôme Declerck; Véronique Gouverneur

doi:10.1002/anie.200803897

Fluorous synthesis of ¹⁸F radiotracers with the [ ¹⁸F]fluoride ion: Nucleophilic fluorination as the detagging process

Romain Bejot, Thomas Fowler, Laurence Carroll, Sophie Boldon, Jane E. Moore, Jérôme Declerck, Véronique Gouverneur

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Tag team: The flouro-detagging of flourous sulfonates by the [ ¹⁸F]fluoride ion was found to be an advantageous strategy for the preparation of various ¹⁸F-labeled prosthetic groups and known radiotracers (see picture). Fluorous solid phase extraction (FSPE) was used to separate the excess fluorous precursor from the labeled material, which suggests that traditional purification protocols such as distillation or tedious separation can be avoided. (Chemical Equation Presented).

Original language	English (US)
Pages (from-to)	586-589
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	3
DOIs	https://doi.org/10.1002/anie.200803897
State	Published - Jan 5 2009
Externally published	Yes

Keywords

Fluorine
Positron emission tomography
Radiopharmaceuticals
Synthetic methods

ASJC Scopus subject areas

Catalysis
Chemistry(all)

Access to Document

10.1002/anie.200803897

Cite this

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abstract = "Tag team: The flouro-detagging of flourous sulfonates by the [ 18F]fluoride ion was found to be an advantageous strategy for the preparation of various 18F-labeled prosthetic groups and known radiotracers (see picture). Fluorous solid phase extraction (FSPE) was used to separate the excess fluorous precursor from the labeled material, which suggests that traditional purification protocols such as distillation or tedious separation can be avoided. (Chemical Equation Presented).",

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AU - Boldon, Sophie

AU - Moore, Jane E.

AU - Declerck, Jérôme

AU - Gouverneur, Véronique

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AB - Tag team: The flouro-detagging of flourous sulfonates by the [ 18F]fluoride ion was found to be an advantageous strategy for the preparation of various 18F-labeled prosthetic groups and known radiotracers (see picture). Fluorous solid phase extraction (FSPE) was used to separate the excess fluorous precursor from the labeled material, which suggests that traditional purification protocols such as distillation or tedious separation can be avoided. (Chemical Equation Presented).

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KW - Synthetic methods

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