Fluoroquinolone resistance linked to both gyrA and parC mutations in the quinolone resistance-determining region of Shigella dysenteriae type 1

Kaisar A. Talukder; Bijay K. Khajanchi; Mohammad A. Islam; Zhahirul Islam; Dilip K. Dutta; Mustafizur Rahman; Haruo Watanabe; Gopinath B. Nair; David A. Sack

doi:10.1007/s00284-005-0140-9

Fluoroquinolone resistance linked to both gyrA and parC mutations in the quinolone resistance-determining region of Shigella dysenteriae type 1

Kaisar A. Talukder, Bijay K. Khajanchi, Mohammad A. Islam, Zhahirul Islam, Dilip K. Dutta, Mustafizur Rahman, Haruo Watanabe, Gopinath B. Nair, David A. Sack

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

We examined the quinolone resistance-determining region (QRDR) of gyrA, gyrB, and parC of recently isolated fluoroquinolone-resistant S. dysenteriae type 1 strains from south Asia and compared data with fluoroquinolone- susceptible strains associated with previous epidemics of 1978, 1984, and 1994. In fluoroquinolone-resistant strains, double mutations (Ser⁸³ → Leu, Asp⁸⁷ → Asn or Gly) and a single mutation (Ser⁸⁰ → Ile) were detected in the QRDRs of gyrA and parC, respectively.

Original language	English (US)
Pages (from-to)	108-111
Number of pages	4
Journal	Current Microbiology
Volume	52
Issue number	2
DOIs	https://doi.org/10.1007/s00284-005-0140-9
State	Published - Feb 2006
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Applied Microbiology and Biotechnology

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title = "Fluoroquinolone resistance linked to both gyrA and parC mutations in the quinolone resistance-determining region of Shigella dysenteriae type 1",

abstract = "We examined the quinolone resistance-determining region (QRDR) of gyrA, gyrB, and parC of recently isolated fluoroquinolone-resistant S. dysenteriae type 1 strains from south Asia and compared data with fluoroquinolone- susceptible strains associated with previous epidemics of 1978, 1984, and 1994. In fluoroquinolone-resistant strains, double mutations (Ser83 → Leu, Asp87 → Asn or Gly) and a single mutation (Ser80 → Ile) were detected in the QRDRs of gyrA and parC, respectively.",

author = "Talukder, {Kaisar A.} and Khajanchi, {Bijay K.} and Islam, {Mohammad A.} and Zhahirul Islam and Dutta, {Dilip K.} and Mustafizur Rahman and Haruo Watanabe and Nair, {Gopinath B.} and Sack, {David A.}",

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AU - Talukder, Kaisar A.

AU - Khajanchi, Bijay K.

AU - Islam, Mohammad A.

AU - Islam, Zhahirul

AU - Dutta, Dilip K.

AU - Rahman, Mustafizur

AU - Watanabe, Haruo

AU - Nair, Gopinath B.

AU - Sack, David A.

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N2 - We examined the quinolone resistance-determining region (QRDR) of gyrA, gyrB, and parC of recently isolated fluoroquinolone-resistant S. dysenteriae type 1 strains from south Asia and compared data with fluoroquinolone- susceptible strains associated with previous epidemics of 1978, 1984, and 1994. In fluoroquinolone-resistant strains, double mutations (Ser83 → Leu, Asp87 → Asn or Gly) and a single mutation (Ser80 → Ile) were detected in the QRDRs of gyrA and parC, respectively.

AB - We examined the quinolone resistance-determining region (QRDR) of gyrA, gyrB, and parC of recently isolated fluoroquinolone-resistant S. dysenteriae type 1 strains from south Asia and compared data with fluoroquinolone- susceptible strains associated with previous epidemics of 1978, 1984, and 1994. In fluoroquinolone-resistant strains, double mutations (Ser83 → Leu, Asp87 → Asn or Gly) and a single mutation (Ser80 → Ile) were detected in the QRDRs of gyrA and parC, respectively.

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Fluoroquinolone resistance linked to both gyrA and parC mutations in the quinolone resistance-determining region of Shigella dysenteriae type 1

Abstract

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