Fluorogenic N-Nitrosoamides: Active-Site Labeling Reagents for Chymotrypsin-like Proteases

Min Li, Emil H. White

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Two fluorogenic N-nitrosoamides, N-nitroso-N-((7-methoxycoumarin-4-yl)methyl)-N′-isobutyrylalaninamide (6a) and N-nitroso-N-((6-methoxyquinolin-2-yl)methyl)-N′-isobutyrylalaninainide (6b), were synthesized. Both N-nitrosoamides inhibited α-chymotrypsin irreversibly; they show promise as labeling reagents for the active sites of chymotrypsin-like proteases.

Original languageEnglish (US)
Pages (from-to)454-458
Number of pages5
JournalBioconjugate Chemistry
Volume5
Issue number5
DOIs
StatePublished - Sep 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

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