Abstract
Two fluorogenic N-nitrosoamides, N-nitroso-N-((7-methoxycoumarin-4-yl)methyl)-N′-isobutyrylalaninamide (6a) and N-nitroso-N-((6-methoxyquinolin-2-yl)methyl)-N′-isobutyrylalaninainide (6b), were synthesized. Both N-nitrosoamides inhibited α-chymotrypsin irreversibly; they show promise as labeling reagents for the active sites of chymotrypsin-like proteases.
Original language | English (US) |
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Pages (from-to) | 454-458 |
Number of pages | 5 |
Journal | Bioconjugate Chemistry |
Volume | 5 |
Issue number | 5 |
DOIs | |
State | Published - Sep 1 1994 |
Externally published | Yes |
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Biomedical Engineering
- Pharmacology
- Pharmaceutical Science
- Organic Chemistry