Fluorescent photon migration theory for turbid biological media

Amir H. Gandjbakhche; Robert F. Bonner; Israel Gannot; Jay R. Knutson; Reza Navai; Ralph J. Nossal; George H. Weiss

doi:10.1117/12.237577

Fluorescent photon migration theory for turbid biological media

Amir H. Gandjbakhche, Robert F. Bonner, Israel Gannot, Jay R. Knutson, Reza Navai, Ralph J. Nossal, George H. Weiss

Research output: Contribution to journal › Conference article › peer-review

4 Scopus citations

Abstract

Fluorescence imaging in situ may provide highly specific identification of cell types and altered metabolic activity near the surface of tissue. Most approaches to developing the necessary analytical framework for quantitative 3-D use are based on numerical solutions of some form of transport equation. These are highly computer-intensive and can only be carried out for specified parameters. We apply a random walk model for photon migration which enables us to find an exact expression for the frequency-dependent fluorescent signal emitted from the site of a single fluorophore. Our general expression allows for broad variation of the degree of absorptivity, and is potentially important in providing a basis for the development of fluorescence image reconstruction algorithms.

Original language	English (US)
Pages (from-to)	8-15
Number of pages	8
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	2679
DOIs	https://doi.org/10.1117/12.237577
State	Published - Dec 1 1996
Externally published	Yes
Event	Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases III: Optical Biopsy - San Jose, CA, United States Duration: Jan 29 1996 → Jan 29 1996

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.237577

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title = "Fluorescent photon migration theory for turbid biological media",

abstract = "Fluorescence imaging in situ may provide highly specific identification of cell types and altered metabolic activity near the surface of tissue. Most approaches to developing the necessary analytical framework for quantitative 3-D use are based on numerical solutions of some form of transport equation. These are highly computer-intensive and can only be carried out for specified parameters. We apply a random walk model for photon migration which enables us to find an exact expression for the frequency-dependent fluorescent signal emitted from the site of a single fluorophore. Our general expression allows for broad variation of the degree of absorptivity, and is potentially important in providing a basis for the development of fluorescence image reconstruction algorithms.",

author = "Gandjbakhche, {Amir H.} and Bonner, {Robert F.} and Israel Gannot and Knutson, {Jay R.} and Reza Navai and Nossal, {Ralph J.} and Weiss, {George H.}",

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T1 - Fluorescent photon migration theory for turbid biological media

AU - Gandjbakhche, Amir H.

AU - Bonner, Robert F.

AU - Gannot, Israel

AU - Knutson, Jay R.

AU - Navai, Reza

AU - Nossal, Ralph J.

AU - Weiss, George H.

PY - 1996/12/1

Y1 - 1996/12/1

N2 - Fluorescence imaging in situ may provide highly specific identification of cell types and altered metabolic activity near the surface of tissue. Most approaches to developing the necessary analytical framework for quantitative 3-D use are based on numerical solutions of some form of transport equation. These are highly computer-intensive and can only be carried out for specified parameters. We apply a random walk model for photon migration which enables us to find an exact expression for the frequency-dependent fluorescent signal emitted from the site of a single fluorophore. Our general expression allows for broad variation of the degree of absorptivity, and is potentially important in providing a basis for the development of fluorescence image reconstruction algorithms.

AB - Fluorescence imaging in situ may provide highly specific identification of cell types and altered metabolic activity near the surface of tissue. Most approaches to developing the necessary analytical framework for quantitative 3-D use are based on numerical solutions of some form of transport equation. These are highly computer-intensive and can only be carried out for specified parameters. We apply a random walk model for photon migration which enables us to find an exact expression for the frequency-dependent fluorescent signal emitted from the site of a single fluorophore. Our general expression allows for broad variation of the degree of absorptivity, and is potentially important in providing a basis for the development of fluorescence image reconstruction algorithms.

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JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

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Y2 - 29 January 1996 through 29 January 1996

ER -

Fluorescent photon migration theory for turbid biological media

Abstract

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