@article{6043e3756cbd4da9bb7ce89d1f443702,
title = "Fluorescein angiographic findings in presumed histoplasmosis",
abstract = "Thirty-eight patients with presumed ocular histoplasmosis were studied by fluorescein angiography in different stages of the disease. In the nonhemorrhagic lesions, the area of retinal edema was clearly demonstrated in the angiograms as an area of late diffuse fluorescence which disappeared when the lesion healed. The structure of small hemorrhagic lesions was similar to that of nonhemorrhagic lesions and definite vessel loops could be demonstrated in a few of them in the central whitish elevation. In large hemorrhagic lesions, a network of large capillaries was always demonstrated and the changes in the size and shape of the lesions corresponded to changes in the vessel net. Fluorescein angiography offers an objective way of documenting the changes in hemorrhagic central lesions during different trials of therapy.",
author = "Lea Hyv{\"a}rinen and Lerer, {Robert J.} and Knox, {David L.}",
note = "Funding Information: In 1960, Woods and Wahlen1 focused at tention on the relationship between hemorrhagic macular lesion in young individuals and positive skin test for histoplasmosis. This relationship has been found also in other patient studies.2*5 Histoplasmosis is widespread in the United States and in other areas of the world,6 with some areas recording 90% positive skin tests in 20-year-old residents.7 In spite of the high rate of infectivity, systemic disease is seen relatively infrequently and death from the infection is a rarity. The clinical picture of presumed ocular histoplasmosis has been described in detail in a number of works.815 Study of this group of patients reveals that many have scars in their fundi and have no history of symptoms compatible with an active inflammation. Among patients who were followed closely, an active process has been seen developing immediately adjacent to or around an old scar. Most patients present with loss of acuity or metamorphopsia of weeks or months in duration and are found to have an active lesion in which subretinal hemorrhage is associated with further reduction in acuity. This paper describes the fluorescein angiographic findings in a group of patients with presumed histoplasmosis syndrome. The technique is valuable in the study of various From the Wilmer Institute of The Johns Hopkins Hospital and the Johns Hopkins University School of Medicine, Baltimore, Maryland. This work was supported in part by NIH Training Grant NB 05217-10 and in part by unrestricted Grant M.28.21.34 from Research to Prevent Blindness, Inc. Dr. Lerer is the recipient of an undergraduate research fellowship from The Seeing Eye, Inc., Morristown, New Jersey. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",
year = "1971",
month = feb,
doi = "10.1016/0002-9394(71)90117-6",
language = "English (US)",
volume = "71",
pages = "449--459",
journal = "American journal of ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "2",
}