FKBP12-binding domain analogues of FK506 are potent, nonimmunosuppressive neurotrophic agents in vitro and promote recovery in a mouse model of Parkinson's disease

G. S. Hamilton; W. Huang; M. A. Connolly; D. T. Ross; H. Guo; H. L. Valentine; P. D. Suzdak; J. P. Steiner

doi:10.1016/S0960-894X(97)00304-1

FKBP12-binding domain analogues of FK506 are potent, nonimmunosuppressive neurotrophic agents in vitro and promote recovery in a mouse model of Parkinson's disease

G. S. Hamilton, W. Huang, M. A. Connolly, D. T. Ross, H. Guo, H. L. Valentine, P. D. Suzdak, J. P. Steiner

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

A series of simple N-(glyoxyl)pipecolate esters were synthesized as mimics of the FKBP12- binding domain portion of FK506. Compounds which were effective inhibitors of the prolyl isomerase activity of FKBP12 were extraordinarily potent neurotrophic agents in vitro, and were effective in a mouse model of Parkinson's Disease. These results suggest that FKBP12 ligands have therapeutic utility in neurodegenerative diseases.

Original language	English (US)
Pages (from-to)	1785-1790
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	13
DOIs	https://doi.org/10.1016/S0960-894X(97)00304-1
State	Published - Jul 8 1997
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(97)00304-1

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Hamilton, G. S., Huang, W., Connolly, M. A., Ross, D. T., Guo, H., Valentine, H. L., Suzdak, P. D., & Steiner, J. P. (1997). FKBP12-binding domain analogues of FK506 are potent, nonimmunosuppressive neurotrophic agents in vitro and promote recovery in a mouse model of Parkinson's disease. Bioorganic and Medicinal Chemistry Letters, 7(13), 1785-1790. https://doi.org/10.1016/S0960-894X(97)00304-1

FKBP12-binding domain analogues of FK506 are potent, nonimmunosuppressive neurotrophic agents in vitro and promote recovery in a mouse model of Parkinson's disease. / Hamilton, G. S.; Huang, W.; Connolly, M. A. et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 7, No. 13, 08.07.1997, p. 1785-1790.

Research output: Contribution to journal › Article › peer-review

Hamilton, GS, Huang, W, Connolly, MA, Ross, DT, Guo, H, Valentine, HL, Suzdak, PD & Steiner, JP 1997, 'FKBP12-binding domain analogues of FK506 are potent, nonimmunosuppressive neurotrophic agents in vitro and promote recovery in a mouse model of Parkinson's disease', Bioorganic and Medicinal Chemistry Letters, vol. 7, no. 13, pp. 1785-1790. https://doi.org/10.1016/S0960-894X(97)00304-1

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AU - Suzdak, P. D.

AU - Steiner, J. P.

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FKBP12-binding domain analogues of FK506 are potent, nonimmunosuppressive neurotrophic agents in vitro and promote recovery in a mouse model of Parkinson's disease

Abstract

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