TY - JOUR
T1 - First-borns carry a higher metabolic risk in early adulthood
T2 - Evidence from a prospective cohort study
AU - Siervo, Mario
AU - Horta, Bernardo L.
AU - Stephan, Blossom C M
AU - Victora, Cesar G.
AU - Wells, Jonathan C K
PY - 2010
Y1 - 2010
N2 - Background: Birth order has been associated with early growth variability and subsequent increased adiposity, but the consequent effects of increased fat mass on metabolic risk during adulthood have not been assessed. We aimed to quantify the metabolic risk in young adulthood of being first-born relative to those born second or subsequently. Methodology and Principal Findings:Body composition and metabolic risk were assessed in 2,249 men, aged 17-19 years, from a birth cohort in southern Brazil. Metabolic risk was assessed using a composite z-score integrating standardized measurements of blood pressure, total cholesterol, high density lipoprotein, triglycerides and fat mass. First-borns had lower birth weight z-score (δ= 20.25, 95%CI 20.35, 20.15,p
AB - Background: Birth order has been associated with early growth variability and subsequent increased adiposity, but the consequent effects of increased fat mass on metabolic risk during adulthood have not been assessed. We aimed to quantify the metabolic risk in young adulthood of being first-born relative to those born second or subsequently. Methodology and Principal Findings:Body composition and metabolic risk were assessed in 2,249 men, aged 17-19 years, from a birth cohort in southern Brazil. Metabolic risk was assessed using a composite z-score integrating standardized measurements of blood pressure, total cholesterol, high density lipoprotein, triglycerides and fat mass. First-borns had lower birth weight z-score (δ= 20.25, 95%CI 20.35, 20.15,p
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U2 - 10.1371/journal.pone.0013907
DO - 10.1371/journal.pone.0013907
M3 - Article
C2 - 21085691
AN - SCOPUS:78649757872
SN - 1932-6203
VL - 5
JO - PLoS One
JF - PLoS One
IS - 11
M1 - e13907
ER -