Fine mapping of an Alzheimer Disease-associated gene encoding beta-amyloid protein

Edmund C. Jenkins, Evelyn A. Devine-Gage, Nikolaos K. Robakis, Xiu Lan Yao, W. Ted Brown, George E. Houck, Gloria Wolfe, Narayanarao Ramakrishna, Wayne P. Silverman, Henryk M. Wisniewski

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


We have sublocalized an Alzheimer Disease-associated gene, which encodes for cerebrovascular beta-amyloid protein, to the region from the centromere through the proximal half of band 21q21 using both somatic cell and insitu mapping techniques. In addition we found repeatedly significant but weaker hybridization of the beta-amyloid protein probe to the short arm of chromosome 20. 794 cells were analyzed from whole blood, lymphoblastoid and skin cultures. The latter two types of cultures had parts of the 21st chromosome translocated to other chromosomes facilitating sublocalization.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalBiochemical and Biophysical Research Communications
Issue number1
StatePublished - Feb 29 1988
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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