Previous studies have implicated the genes G72 and G30, on chromosome 13q33, in both schizophrenia and bipolar disorder. In this issue, Chen et al show that the reported association between bipolar disorder and markers near these genes can be reproduced in an independent sample. The new findings involve different alleles than those reported previously, suggesting a complex relationship between disease and genetic variation at this locus. Further studies are needed to identify variants that alter function and modify disease risk.
|Published - 2004
ASJC Scopus subject areas
- Psychiatry and Mental health
- Cellular and Molecular Neuroscience
- Molecular Biology