Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33

Y. S. Chen, N. Akula, S. D. Detera-Wadleigh, T. G. Schulze, J. Thomas, J. B. Potash, J. R. DePaulo, Melvin Mcinnis, N. J. Cox, Francis Joseph McMahon

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Previous studies have implicated the genes G72 and G30, on chromosome 13q33, in both schizophrenia and bipolar disorder. In this issue, Chen et al show that the reported association between bipolar disorder and markers near these genes can be reproduced in an independent sample. The new findings involve different alleles than those reported previously, suggesting a complex relationship between disease and genetic variation at this locus. Further studies are needed to identify variants that alter function and modify disease risk.

Original languageEnglish (US)
Pages (from-to)5+3
JournalMolecular psychiatry
Volume9
Issue number1
StatePublished - 2004

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Molecular Biology

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