Fidelity at the Molecular Level: Lessons from Protein Synthesis

Hani S. Zaher, Rachel Green

Research output: Contribution to journalReview articlepeer-review

251 Scopus citations


The faithful and rapid translation of genetic information into peptide sequences is an indispensable property of the ribosome. The mechanistic understanding of strategies used by the ribosome to achieve both speed and fidelity during translation results from nearly a half century of biochemical and structural studies. Emerging from these studies is the common theme that the ribosome uses local as well as remote conformational switches to govern induced-fit mechanisms that ensure accuracy in codon recognition during both tRNA selection and translation termination.

Original languageEnglish (US)
Pages (from-to)746-762
Number of pages17
Issue number4
StatePublished - Feb 20 2009

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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