Fibulin-7 C-terminal fragment and its active synthetic peptide suppress choroidal and retinal neovascularization

Tomoko Ikeuchi, Yogita Kanan, Da Long, Susana de Vega, Kentaro Hozumi, Motoyoshi Nomizu, Peter A. Campochiaro, Yoshihiko Yamada

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Wet age-related macular degeneration (AMD) and diabetic retinopathy are the leading causes of blindness through increased angiogenesis. Although VEGF-neutralizing proteins provide benefit, inconsistent responses indicate a need for new therapies. We previously identified the Fibulin-7 C-terminal fragment (Fbln7-C) as an angiogenesis inhibitor in vitro. Here we show that Fbln7-C inhibits neovascularization in vivo, in both a model of wet AMD involving choroidal neovascularization (CNV) and diabetic retinopathy involving oxygen-induced ischemic retinopathy. Furthermore, a short peptide sequence from Fbln7-C is responsible for the anti-angiogenic properties of Fbln7-C. Our work suggests Fbln7-C as a therapeutic candidate for wet AMD and ischemic retinopathy.

Original languageEnglish (US)
Article number103986
JournalMicrovascular Research
Volume129
DOIs
StatePublished - May 2020

Keywords

  • AMD
  • Angiogenesis
  • ECM
  • Fibulin-7
  • Peptides
  • Retinopathy

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

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