Fibrous myopathy. A rheumatic complication of drug abuse

Kent R. Johnson, Willa A. Hsueh, Sheldon M. Glusman, Frank C. Arnett

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


A progressive fibrous myopathy may result from chronic intramuscular drug abuse. This complication may mimic other rheumatic disorders and early recognition may prevent disability. The patient described here presented with fixed flexion and extension contracture of hips and knees, respectively, after abusing meperidine and other agents for 3 years. Soft tissues of thighs and buttocks were “wood hard,” EMG showed absence of action potentials in affected muscles, and biopsy revealed extensive replacement of muscle with dense, acellular fibrous tissue. Possible mechanisms are discussed.

Original languageEnglish (US)
Pages (from-to)923-926
Number of pages4
JournalArthritis & Rheumatism
Issue number5
StatePublished - 1976
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)


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