Fibrous Mesothelioma with Hypoglycemic Psychosis and Coma

Claude R. Garfield, Henry V. Belcher, John S. Shuttleworth

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The syndrome of large nonpancreatic tumors with hypoglycemia has been recognized as a clinical entity. A spindletype of cell predominates in these tumors; they are located in the thorax or abdomen and generally attain a massive size before symptoms of hypoglycemia appear. The patient here described, when admitted to the hospital, had a large abdominal mass; he was maniacal and later became comatose. Intravenous administration of glucose caused striking temporary improvement. Surgical extirpation of a large retroperitoneal mesothelioma was followed by a lasting stabilization of the blood sugar and glucose tolerance within normal limits. Biologic assay of tumor tissue and plasma in this case did not reveal any increased insulin-like activity.

Original languageEnglish (US)
Pages (from-to)380-385
Number of pages6
JournalJAMA: The Journal of the American Medical Association
Issue number5
StatePublished - Aug 4 1962

ASJC Scopus subject areas

  • Medicine(all)


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