Fibrosis, gene expression and orbital inflammatory disease

James T. Rosenbaum; Dongseok Choi; David J. Wilson; Hans E. Grossniklaus; Christina A. Harrington; Roger A. Dailey; John D. Ng; Eric A. Steele; Craig N. Czyz; Jill A. Foster; David Tse; Chris Alabiad; Sander Dubovy; Prashant Parekh; Gerald J. Harris; Michael Kazim; Payal Patel; Valerie White; Peter Dolman; Deepak P. Edward; Hind Alkatan; Hailahal Hussain; Dinesh Selva; Patrick Yeatts; Bobby Korn; Don Kikkawa; Patrick Stauffer; Stephen R. Planck

doi:10.1136/bjophthalmol-2015-306614

Fibrosis, gene expression and orbital inflammatory disease

James T. Rosenbaum
, Dongseok Choi
, David J. Wilson
, Hans E. Grossniklaus
, Christina A. Harrington
, Roger A. Dailey
, John D. Ng
, Eric A. Steele
, Craig N. Czyz
, Jill A. Foster
, David Tse
, Chris Alabiad
, Sander Dubovy
, Prashant Parekh
, Gerald J. Harris
, Michael Kazim
, Payal Patel
, Valerie White
, Peter Dolman
, Deepak P. Edward

Hind Alkatan, Hailahal Hussain, Dinesh Selva, Patrick Yeatts, Bobby Korn, Don Kikkawa, Patrick Stauffer, Stephen R. Planck

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Background/Aims: To clarify the pathogenesis of fibrosis in inflammatory orbital diseases, we analysed the gene expression in orbital biopsies and compared our Results: with those reported for idiopathic pulmonary fibrosis. Methods: We collected 140 biopsies from 138 patients (58 lacrimal glands; 82 orbital fat). Diagnoses included healthy controls (n=27), non-specific orbital inflammation (NSOI) (n=61), thyroid eye disease (TED) (n=29), sarcoidosis (n=14) and granulomatosis with polyangiitis (GPA) (n=7). Fibrosis was scored on a 0-3 scale by two experts, ophthalmic pathologists. Gene expression was quantified using Affymetrix U133 plus 2.0 microarray. Results: Within orbital fat, fibrosis was greatest among subjects with GPA (2.75±0.46) and significantly increased in tissue from subjects with GPA, NSOI or sarcoidosis ( p

Original language	English (US)
Pages (from-to)	1424-1429
Number of pages	6
Journal	British Journal of Ophthalmology
Volume	99
Issue number	10
DOIs	https://doi.org/10.1136/bjophthalmol-2015-306614
State	Published - Oct 1 2015
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience
General Medicine

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10.1136/bjophthalmol-2015-306614

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Rosenbaum, J. T., Choi, D., Wilson, D. J., Grossniklaus, H. E., Harrington, C. A., Dailey, R. A., Ng, J. D., Steele, E. A., Czyz, C. N., Foster, J. A., Tse, D., Alabiad, C., Dubovy, S., Parekh, P., Harris, G. J., Kazim, M., Patel, P., White, V., Dolman, P., ... Planck, S. R. (2015). Fibrosis, gene expression and orbital inflammatory disease. British Journal of Ophthalmology, 99(10), 1424-1429. https://doi.org/10.1136/bjophthalmol-2015-306614

Rosenbaum, JT, Choi, D, Wilson, DJ, Grossniklaus, HE, Harrington, CA, Dailey, RA, Ng, JD, Steele, EA, Czyz, CN, Foster, JA, Tse, D, Alabiad, C, Dubovy, S, Parekh, P, Harris, GJ, Kazim, M, Patel, P, White, V, Dolman, P, Edward, DP, Alkatan, H, Hussain, H, Selva, D, Yeatts, P, Korn, B, Kikkawa, D, Stauffer, P & Planck, SR 2015, 'Fibrosis, gene expression and orbital inflammatory disease', British Journal of Ophthalmology, vol. 99, no. 10, pp. 1424-1429. https://doi.org/10.1136/bjophthalmol-2015-306614

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title = "Fibrosis, gene expression and orbital inflammatory disease",

abstract = "Background/Aims: To clarify the pathogenesis of fibrosis in inflammatory orbital diseases, we analysed the gene expression in orbital biopsies and compared our Results: with those reported for idiopathic pulmonary fibrosis. Methods: We collected 140 biopsies from 138 patients (58 lacrimal glands; 82 orbital fat). Diagnoses included healthy controls (n=27), non-specific orbital inflammation (NSOI) (n=61), thyroid eye disease (TED) (n=29), sarcoidosis (n=14) and granulomatosis with polyangiitis (GPA) (n=7). Fibrosis was scored on a 0-3 scale by two experts, ophthalmic pathologists. Gene expression was quantified using Affymetrix U133 plus 2.0 microarray. Results: Within orbital fat, fibrosis was greatest among subjects with GPA (2.75±0.46) and significantly increased in tissue from subjects with GPA, NSOI or sarcoidosis ( p",

author = "Rosenbaum, \{James T.\} and Dongseok Choi and Wilson, \{David J.\} and Grossniklaus, \{Hans E.\} and Harrington, \{Christina A.\} and Dailey, \{Roger A.\} and Ng, \{John D.\} and Steele, \{Eric A.\} and Czyz, \{Craig N.\} and Foster, \{Jill A.\} and David Tse and Chris Alabiad and Sander Dubovy and Prashant Parekh and Harris, \{Gerald J.\} and Michael Kazim and Payal Patel and Valerie White and Peter Dolman and Edward, \{Deepak P.\} and Hind Alkatan and Hailahal Hussain and Dinesh Selva and Patrick Yeatts and Bobby Korn and Don Kikkawa and Patrick Stauffer and Planck, \{Stephen R.\}",

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AU - Rosenbaum, James T.

AU - Choi, Dongseok

AU - Wilson, David J.

AU - Grossniklaus, Hans E.

AU - Harrington, Christina A.

AU - Dailey, Roger A.

AU - Ng, John D.

AU - Steele, Eric A.

AU - Czyz, Craig N.

AU - Foster, Jill A.

AU - Tse, David

AU - Alabiad, Chris

AU - Dubovy, Sander

AU - Parekh, Prashant

AU - Harris, Gerald J.

AU - Kazim, Michael

AU - Patel, Payal

AU - White, Valerie

AU - Dolman, Peter

AU - Edward, Deepak P.

AU - Alkatan, Hind

AU - Hussain, Hailahal

AU - Selva, Dinesh

AU - Yeatts, Patrick

AU - Korn, Bobby

AU - Kikkawa, Don

AU - Stauffer, Patrick

AU - Planck, Stephen R.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Background/Aims: To clarify the pathogenesis of fibrosis in inflammatory orbital diseases, we analysed the gene expression in orbital biopsies and compared our Results: with those reported for idiopathic pulmonary fibrosis. Methods: We collected 140 biopsies from 138 patients (58 lacrimal glands; 82 orbital fat). Diagnoses included healthy controls (n=27), non-specific orbital inflammation (NSOI) (n=61), thyroid eye disease (TED) (n=29), sarcoidosis (n=14) and granulomatosis with polyangiitis (GPA) (n=7). Fibrosis was scored on a 0-3 scale by two experts, ophthalmic pathologists. Gene expression was quantified using Affymetrix U133 plus 2.0 microarray. Results: Within orbital fat, fibrosis was greatest among subjects with GPA (2.75±0.46) and significantly increased in tissue from subjects with GPA, NSOI or sarcoidosis ( p

AB - Background/Aims: To clarify the pathogenesis of fibrosis in inflammatory orbital diseases, we analysed the gene expression in orbital biopsies and compared our Results: with those reported for idiopathic pulmonary fibrosis. Methods: We collected 140 biopsies from 138 patients (58 lacrimal glands; 82 orbital fat). Diagnoses included healthy controls (n=27), non-specific orbital inflammation (NSOI) (n=61), thyroid eye disease (TED) (n=29), sarcoidosis (n=14) and granulomatosis with polyangiitis (GPA) (n=7). Fibrosis was scored on a 0-3 scale by two experts, ophthalmic pathologists. Gene expression was quantified using Affymetrix U133 plus 2.0 microarray. Results: Within orbital fat, fibrosis was greatest among subjects with GPA (2.75±0.46) and significantly increased in tissue from subjects with GPA, NSOI or sarcoidosis ( p

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Fibrosis, gene expression and orbital inflammatory disease

Abstract

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