TY - JOUR
T1 - Fibroblasts in cancer
T2 - Unity in heterogeneity
AU - Chhabra, Yash
AU - Weeraratna, Ashani T.
N1 - Funding Information:
We apologize for omitting relevant works and citations due to space constraints. A.T.W. is also supported by P01CA114046 ( NCI ), U01CA227550 ( NCI ), R01CA232256 ( NCI ), R01CA207935 ( NCI ), a Bloomberg Distinguished Professorship and the EV McCollum Endowed Chair.
Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2023/4/13
Y1 - 2023/4/13
N2 - Tumor cells do not exist in isolation in vivo, and carcinogenesis depends on the surrounding tumor microenvironment (TME), composed of a myriad of cell types and biophysical and biochemical components. Fibroblasts are integral in maintaining tissue homeostasis. However, even before a tumor develops, pro-tumorigenic fibroblasts in close proximity can provide the fertile ‘soil’ to the cancer ‘seed’ and are known as cancer-associated fibroblasts (CAFs). In response to intrinsic and extrinsic stressors, CAFs reorganize the TME enabling metastasis, therapeutic resistance, dormancy and reactivation by secreting cellular and acellular factors. In this review, we summarize the recent discoveries on CAF-mediated cancer progression with a particular focus on fibroblast heterogeneity and plasticity.
AB - Tumor cells do not exist in isolation in vivo, and carcinogenesis depends on the surrounding tumor microenvironment (TME), composed of a myriad of cell types and biophysical and biochemical components. Fibroblasts are integral in maintaining tissue homeostasis. However, even before a tumor develops, pro-tumorigenic fibroblasts in close proximity can provide the fertile ‘soil’ to the cancer ‘seed’ and are known as cancer-associated fibroblasts (CAFs). In response to intrinsic and extrinsic stressors, CAFs reorganize the TME enabling metastasis, therapeutic resistance, dormancy and reactivation by secreting cellular and acellular factors. In this review, we summarize the recent discoveries on CAF-mediated cancer progression with a particular focus on fibroblast heterogeneity and plasticity.
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U2 - 10.1016/j.cell.2023.03.016
DO - 10.1016/j.cell.2023.03.016
M3 - Review article
C2 - 37059066
AN - SCOPUS:85151516294
SN - 0092-8674
VL - 186
SP - 1580
EP - 1609
JO - Cell
JF - Cell
IS - 8
ER -