Fiber-optic endomicroscopy system for high-resolution nonlinear imaging of biological tissue

Yicong Wu; Jiefeng Xi; Michael J. Cobb; Xingde Li

Fiber-optic endomicroscopy system for high-resolution nonlinear imaging of biological tissue

Yicong Wu, Jiefeng Xi, Michael J. Cobb, Xingde Li

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A flexible fiber-optic endomicroscopy system was developed for nonlinear optical imaging of biological samples. Double-clad fiber and photonic bandgap fiber were employed in the endomicroscope for femtosecond pulse delivery, dispersion compensation, nonlinear optical signals collection and fast beam scanning. Three-dimensional imaging of biological tissues based on second harmonic generation and two-photon excited fluorescence was performed with the endomicroscope. The depth-resolved imaging results strongly suggest the potential of this flexible fiber-optic microscope system for real-time assessment of both epithelial and stromal structures in luminal organs.

Original language	English (US)
Title of host publication	Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
Pages	1851-1852
Number of pages	2
State	Published - 2008
Externally published	Yes
Event	30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - Vancouver, BC, Canada Duration: Aug 20 2008 → Aug 25 2008

Publication series

Name	Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"

Other

Other	30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
Country/Territory	Canada
City	Vancouver, BC
Period	8/20/08 → 8/25/08

ASJC Scopus subject areas

Computer Vision and Pattern Recognition
Signal Processing
Biomedical Engineering
Health Informatics

Cite this

Wu, Y., Xi, J., Cobb, M. J., & Li, X. (2008). Fiber-optic endomicroscopy system for high-resolution nonlinear imaging of biological tissue. In Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 (pp. 1851-1852). Article 4649541 (Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology").

Fiber-optic endomicroscopy system for high-resolution nonlinear imaging of biological tissue. / Wu, Yicong; Xi, Jiefeng; Cobb, Michael J. et al.
Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08. 2008. p. 1851-1852 4649541 (Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology").

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Wu, Y, Xi, J, Cobb, MJ & Li, X 2008, Fiber-optic endomicroscopy system for high-resolution nonlinear imaging of biological tissue. in Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08., 4649541, Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology", pp. 1851-1852, 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08, Vancouver, BC, Canada, 8/20/08.

Wu Y, Xi J, Cobb MJ, Li X. Fiber-optic endomicroscopy system for high-resolution nonlinear imaging of biological tissue. In Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08. 2008. p. 1851-1852. 4649541. (Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology").

Wu, Yicong ; Xi, Jiefeng ; Cobb, Michael J. et al. / Fiber-optic endomicroscopy system for high-resolution nonlinear imaging of biological tissue. Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08. 2008. pp. 1851-1852 (Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology").

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abstract = "A flexible fiber-optic endomicroscopy system was developed for nonlinear optical imaging of biological samples. Double-clad fiber and photonic bandgap fiber were employed in the endomicroscope for femtosecond pulse delivery, dispersion compensation, nonlinear optical signals collection and fast beam scanning. Three-dimensional imaging of biological tissues based on second harmonic generation and two-photon excited fluorescence was performed with the endomicroscope. The depth-resolved imaging results strongly suggest the potential of this flexible fiber-optic microscope system for real-time assessment of both epithelial and stromal structures in luminal organs.",

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Fiber-optic endomicroscopy system for high-resolution nonlinear imaging of biological tissue

Abstract

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ASJC Scopus subject areas

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