TY - JOUR
T1 - Fetal response to maternal methadone administration
AU - Jansson, Lauren M.
AU - DiPietro, Janet
AU - Elko, Andrea
N1 - Funding Information:
This work is supported by NIH grants K08 DA00495 awarded to the first author, and R01 HD27592 awarded to the second author.
Funding Information:
The authors thank the subjects, Kathleen Costigan, RN, MPH, Vickie Walters, LCSW-C, Tammy Roberts, Martha Velez, MD, and Hendrée Jones, PhD, for their help in conducting this research. This research was funded by K08-DA00495, NIDA, provided to the first author.
PY - 2005/9
Y1 - 2005/9
N2 - Objective: The purpose of this study was to investigate the effect of methadone on fetal neurobehavioral functions and maternal physiologic indicators. Study design: Forty women attending a substance abuse treatment facility with otherwise uncomplicated pregnancies were evaluated at peak and trough methadone levels. Fetal measures included heart rate, variability, periodic accelerations/decelerations, motor activity, and fetal movement-heart rate coupling. Maternal measures included maternal heart period, variability, electrodermal skin conductance, respiration, and respiratory sinus arrhythmia (RSA). Repeated measure analysis of variance was used to evaluate within-subject changes. Results: At peak methadone, fetal heart rate was slower, less variable, and displayed fewer accelerations. Fetuses displayed less motor activity, and the integration between heart rate and motor activity was attenuated. Maternal heart rate and skin conductance were unchanged, but methadone administration was associated with lower respiratory rate and RSA, an indicator of parasympathetic tone. Conclusion: Maternal methadone administration has significant effects on fetal behavioral functions that are independent of maternal effects.
AB - Objective: The purpose of this study was to investigate the effect of methadone on fetal neurobehavioral functions and maternal physiologic indicators. Study design: Forty women attending a substance abuse treatment facility with otherwise uncomplicated pregnancies were evaluated at peak and trough methadone levels. Fetal measures included heart rate, variability, periodic accelerations/decelerations, motor activity, and fetal movement-heart rate coupling. Maternal measures included maternal heart period, variability, electrodermal skin conductance, respiration, and respiratory sinus arrhythmia (RSA). Repeated measure analysis of variance was used to evaluate within-subject changes. Results: At peak methadone, fetal heart rate was slower, less variable, and displayed fewer accelerations. Fetuses displayed less motor activity, and the integration between heart rate and motor activity was attenuated. Maternal heart rate and skin conductance were unchanged, but methadone administration was associated with lower respiratory rate and RSA, an indicator of parasympathetic tone. Conclusion: Maternal methadone administration has significant effects on fetal behavioral functions that are independent of maternal effects.
KW - Fetal development
KW - Fetal heart rate
KW - Fetal movement
KW - Methadone
KW - Pregnancy
KW - Substance abuse
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U2 - 10.1016/j.ajog.2005.02.075
DO - 10.1016/j.ajog.2005.02.075
M3 - Article
C2 - 16150250
AN - SCOPUS:24344450766
SN - 0002-9378
VL - 193
SP - 611
EP - 617
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 3
ER -