Fetal hepatic haematopoiesis is modulated by arterial blood flow to the liver

Shaun M. Kunisaki; Humberto Azpurua; Julie R. Fuchs; Sara C. Graves; David Zurakowski; Dario O. Fauza

doi:10.1111/j.1365-2141.2006.06183.x

Fetal hepatic haematopoiesis is modulated by arterial blood flow to the liver

Shaun M. Kunisaki, Humberto Azpurua, Julie R. Fuchs, Sara C. Graves, David Zurakowski, Dario O. Fauza

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We describe an as yet unrecognised relationship between fetal hepatic haematopoiesis and arterial blood flow to the liver. To increase hepatic arterial flow, the common bile duct (CBD) was ligated in fetal lambs. Reduction of hepatic arterial flow was accomplished in age-matched animals by hepatic artery (HA) ligation. Multiple analyses performed before term showed a significant increase in haematopoietic cell density in CBD animals when compared with sham controls and HA animals. In contrast, HA animals demonstrated a decrease in liver haematopoietic activity. Fetal hepatic haematopoiesis is dependent upon arterial blood flow to the liver.

Original language	English (US)
Pages (from-to)	330-332
Number of pages	3
Journal	British journal of haematology
Volume	134
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2141.2006.06183.x
State	Published - Aug 2006
Externally published	Yes

Keywords

Fetal haematopoiesis
Fetus
Haematopoiesis
Hepatic artery
Hepatic haematopoiesis

ASJC Scopus subject areas

Hematology

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10.1111/j.1365-2141.2006.06183.x

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title = "Fetal hepatic haematopoiesis is modulated by arterial blood flow to the liver",

abstract = "We describe an as yet unrecognised relationship between fetal hepatic haematopoiesis and arterial blood flow to the liver. To increase hepatic arterial flow, the common bile duct (CBD) was ligated in fetal lambs. Reduction of hepatic arterial flow was accomplished in age-matched animals by hepatic artery (HA) ligation. Multiple analyses performed before term showed a significant increase in haematopoietic cell density in CBD animals when compared with sham controls and HA animals. In contrast, HA animals demonstrated a decrease in liver haematopoietic activity. Fetal hepatic haematopoiesis is dependent upon arterial blood flow to the liver.",

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T1 - Fetal hepatic haematopoiesis is modulated by arterial blood flow to the liver

AU - Kunisaki, Shaun M.

AU - Azpurua, Humberto

AU - Fuchs, Julie R.

AU - Graves, Sara C.

AU - Zurakowski, David

AU - Fauza, Dario O.

PY - 2006/8

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AB - We describe an as yet unrecognised relationship between fetal hepatic haematopoiesis and arterial blood flow to the liver. To increase hepatic arterial flow, the common bile duct (CBD) was ligated in fetal lambs. Reduction of hepatic arterial flow was accomplished in age-matched animals by hepatic artery (HA) ligation. Multiple analyses performed before term showed a significant increase in haematopoietic cell density in CBD animals when compared with sham controls and HA animals. In contrast, HA animals demonstrated a decrease in liver haematopoietic activity. Fetal hepatic haematopoiesis is dependent upon arterial blood flow to the liver.

KW - Fetal haematopoiesis

KW - Fetus

KW - Haematopoiesis

KW - Hepatic artery

KW - Hepatic haematopoiesis

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Fetal hepatic haematopoiesis is modulated by arterial blood flow to the liver

Abstract

Keywords

ASJC Scopus subject areas

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