TY - JOUR
T1 - Fetal heart rate and motor development in overweight and obese pregnant women
AU - Voegtline, Kristin M.
AU - Costigan, Kathleen A.
AU - Henderson, Janice L.
AU - Dipietro, Janet A.
N1 - Funding Information:
This research was supported by National Institute of Child Health and Human Development grant R01 HD 27592 , awarded to JA DiPietro.
Publisher Copyright:
© 2015 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
PY - 2016
Y1 - 2016
N2 - Objective To determine the relationship between maternal prepregnancy body mass index (BMI) and fetal cardiac and motor activity and integration during the second half of pregnancy. Methods Longitudinal data were collected from 610 nonsmoking women with normally progressing pregnancies at three gestational periods (24, 30-32, and 36 weeks) across eight cohorts studied between 1997 and 2013. Fifty minutes of fetal heart rate and motor activity data were collected at each period via actocardiography in a laboratory setting. Data were digitized and analyzed using customized software. Standard BMI categories were computed from maternal prepregnancy weight and height. Participants were stratified into normal weight (n = 401, 65.7%), overweight (n = 137, 22.5%), or obese (n = 72, 11.8%). Results Fetuses of obese women showed lower heart rate variability and fewer accelerations relative to fetuses of normal weight women. Fetuses of both obese and overweight women exhibited more vigorous motor activity than fetuses of normal weight women. Cardiac-somatic integration was reduced in both obese and overweight groups. Findings differed by gestational age at assessment. Conclusions Excess maternal prepregnancy weight in overweight and obese women alters the normal trajectory of fetal cardiac and motor development and their integration, with effects amplified as pregnancy progresses.
AB - Objective To determine the relationship between maternal prepregnancy body mass index (BMI) and fetal cardiac and motor activity and integration during the second half of pregnancy. Methods Longitudinal data were collected from 610 nonsmoking women with normally progressing pregnancies at three gestational periods (24, 30-32, and 36 weeks) across eight cohorts studied between 1997 and 2013. Fifty minutes of fetal heart rate and motor activity data were collected at each period via actocardiography in a laboratory setting. Data were digitized and analyzed using customized software. Standard BMI categories were computed from maternal prepregnancy weight and height. Participants were stratified into normal weight (n = 401, 65.7%), overweight (n = 137, 22.5%), or obese (n = 72, 11.8%). Results Fetuses of obese women showed lower heart rate variability and fewer accelerations relative to fetuses of normal weight women. Fetuses of both obese and overweight women exhibited more vigorous motor activity than fetuses of normal weight women. Cardiac-somatic integration was reduced in both obese and overweight groups. Findings differed by gestational age at assessment. Conclusions Excess maternal prepregnancy weight in overweight and obese women alters the normal trajectory of fetal cardiac and motor development and their integration, with effects amplified as pregnancy progresses.
KW - Fetal heart rate
KW - Fetal motor activity
KW - Maternal overweight
KW - Obesity and pregnancy
KW - Prepregnancy body mass index
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U2 - 10.1016/j.ijgo.2015.08.006
DO - 10.1016/j.ijgo.2015.08.006
M3 - Article
C2 - 26797193
AN - SCOPUS:84954285348
SN - 0020-7292
VL - 133
SP - 103
EP - 107
JO - International Journal of Gynecology and Obstetrics
JF - International Journal of Gynecology and Obstetrics
IS - 1
ER -