Femur: MR imaging-guided radio-frequency ablation in a porcine model - Feasibility study

Andrik J. Aschoff, Elmar M. Merkle, Steven N. Emancipator, Cheryl A. Petersilge, Jeffrey L. Duerk, Jonathan S. Lewin

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


PURPOSE: To determine the feasibility of magnetic resonance (MR) imaging-guided and -monitored radio-frequency (RF) ablation of bone. MATERIALS AND METHODS: Seven femurs were treated in five pigs with use of a 0.2-T open MR imager. An 11-gauge bone marrow needle was percutaneously inserted into the distal femur metaphysis with MR fluoroscopy (fast imaging with steady-state precession, or FISP, sequences) to introduce an RF electrode into the bone with further image guidance. Thermal ablation was performed for 10 minutes (90°C ± 2 [mean ± SD]). MR follow-up was performed immediately after ablation and again at 7 and 14 days after the procedure (with contrast material-enhanced T1-weighted, T2-weighted, and fast short inversion time inversion-recovery, or STIR, sequences). The animals were sacrificed at day 14. The femurs were sliced, decalcified, and stained. Image analysis was performed to measure lesion diameter and contrast-to-noise ratio (CNR) and to evaluate complications. RESULTS: Technical success was obtained in all animals. The lesion diameter perpendicular to the electrode was 15.4 mm ± 2.7. No significant complications were noted. The thermal lesions displayed low signal intensity with a sharp rim of high signal intensity. T2-weighted images demonstrated the highest CNR and the lowest error in predicting the lesion size immediately after ablation (2.7 mm ± 1.3). Contrast-enhanced T1-weighted images demonstrated the highest accuracy at day 14 (1.0 mm ± 1.0). CONCLUSION: RF ablation of bone with MR imaging as the sole imaging modality is feasible and allows monitoring of the ablation.

Original languageEnglish (US)
Pages (from-to)471-478
Number of pages8
Issue number2
StatePublished - Nov 1 2002
Externally publishedYes


  • Animals
  • Femur, MR
  • Femur, neoplasms
  • Magnetic resonance (MR), guidance
  • Radiofrequency (RF) ablation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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