Fe/Fe oxide nanocomposite particles with large specific absorption rate for hyperthermia

Q. Zeng; I. Baker; J. A. Loudis; Y. Liao; P. J. Hoopes; J. B. Weaver

doi:10.1063/1.2746064

Fe/Fe oxide nanocomposite particles with large specific absorption rate for hyperthermia

Q. Zeng, I. Baker, J. A. Loudis, Y. Liao, P. J. Hoopes, J. B. Weaver

Research output: Contribution to journal › Article › peer-review

Abstract

Using a water-in-oil microemulsion with cetyl trimethyl ammonium bromide as the surfactant, iron was reduced to form a metallic core on which a passivating oxide shell was grown. Transmission electron microscopy, vibrating sample magnetometry, and heating measurements were used to characterize these monodispersed magnetic Fe Fe3 O4 composite nanoparticles with respect to the possible application for magnetic hyperthermia treatments of cancer. The aim is to utilize the fact that an iron core (high saturation magnetization) will give a greater heating effect than iron oxide, while the iron oxide coating will allow the nanoparticles to be observed using magnetic resonance imaging so that therapy can be effectively monitored and targeted. The largest specific absorption rate obtained was 345 Wg under an alternating magnetic field of 150 Oe at 250 kHz.

Original language	English (US)
Article number	233112
Journal	Applied Physics Letters
Volume	90
Issue number	23
DOIs	https://doi.org/10.1063/1.2746064
State	Published - 2007
Externally published	Yes

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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10.1063/1.2746064

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title = "Fe/Fe oxide nanocomposite particles with large specific absorption rate for hyperthermia",

abstract = "Using a water-in-oil microemulsion with cetyl trimethyl ammonium bromide as the surfactant, iron was reduced to form a metallic core on which a passivating oxide shell was grown. Transmission electron microscopy, vibrating sample magnetometry, and heating measurements were used to characterize these monodispersed magnetic Fe Fe3 O4 composite nanoparticles with respect to the possible application for magnetic hyperthermia treatments of cancer. The aim is to utilize the fact that an iron core (high saturation magnetization) will give a greater heating effect than iron oxide, while the iron oxide coating will allow the nanoparticles to be observed using magnetic resonance imaging so that therapy can be effectively monitored and targeted. The largest specific absorption rate obtained was 345 Wg under an alternating magnetic field of 150 Oe at 250 kHz.",

author = "Q. Zeng and I. Baker and Loudis, {J. A.} and Y. Liao and Hoopes, {P. J.} and Weaver, {J. B.}",

note = "Funding Information: This work was supported by Cancer Nanotechnology Working Group (CNWG) at Dartmouth College and the National Institute of Standards and Technologies (NIST) Grant No. 60NANB2D0120. The authors would like to thank Robert Ivkov of Triton Biosystems Inc. for providing the Dextran-coated nanaoparticles.",

year = "2007",

doi = "10.1063/1.2746064",

language = "English (US)",

volume = "90",

journal = "Applied Physics Letters",

issn = "0003-6951",

publisher = "American Institute of Physics",

number = "23",

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T1 - Fe/Fe oxide nanocomposite particles with large specific absorption rate for hyperthermia

AU - Zeng, Q.

AU - Baker, I.

AU - Loudis, J. A.

AU - Liao, Y.

AU - Hoopes, P. J.

AU - Weaver, J. B.

N1 - Funding Information: This work was supported by Cancer Nanotechnology Working Group (CNWG) at Dartmouth College and the National Institute of Standards and Technologies (NIST) Grant No. 60NANB2D0120. The authors would like to thank Robert Ivkov of Triton Biosystems Inc. for providing the Dextran-coated nanaoparticles.

PY - 2007

Y1 - 2007

N2 - Using a water-in-oil microemulsion with cetyl trimethyl ammonium bromide as the surfactant, iron was reduced to form a metallic core on which a passivating oxide shell was grown. Transmission electron microscopy, vibrating sample magnetometry, and heating measurements were used to characterize these monodispersed magnetic Fe Fe3 O4 composite nanoparticles with respect to the possible application for magnetic hyperthermia treatments of cancer. The aim is to utilize the fact that an iron core (high saturation magnetization) will give a greater heating effect than iron oxide, while the iron oxide coating will allow the nanoparticles to be observed using magnetic resonance imaging so that therapy can be effectively monitored and targeted. The largest specific absorption rate obtained was 345 Wg under an alternating magnetic field of 150 Oe at 250 kHz.

AB - Using a water-in-oil microemulsion with cetyl trimethyl ammonium bromide as the surfactant, iron was reduced to form a metallic core on which a passivating oxide shell was grown. Transmission electron microscopy, vibrating sample magnetometry, and heating measurements were used to characterize these monodispersed magnetic Fe Fe3 O4 composite nanoparticles with respect to the possible application for magnetic hyperthermia treatments of cancer. The aim is to utilize the fact that an iron core (high saturation magnetization) will give a greater heating effect than iron oxide, while the iron oxide coating will allow the nanoparticles to be observed using magnetic resonance imaging so that therapy can be effectively monitored and targeted. The largest specific absorption rate obtained was 345 Wg under an alternating magnetic field of 150 Oe at 250 kHz.

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ER -

Fe/Fe oxide nanocomposite particles with large specific absorption rate for hyperthermia

Abstract

ASJC Scopus subject areas

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