@article{a29863b7de3c49f49f885e59d01d5bc6,
title = "Feedback control in intracellular signaling pathways: Regulating chemotaxis in dictyostelium discoideum",
abstract = "Positive and negative feedback loops are used throughout engineering to tradeoff between amplification and robustness. We show how the social amoebae Dictyostelium discoideum uses these same principles to aggregate during starvation, allowing it to survive difficult environmental conditions.",
keywords = "Amplification, Dictyostelium discoideum, Feedback, Robustness, Signal transduction",
author = "Iglesias, {Pablo A.}",
note = "Funding Information: The author is indebted Andre Levchenko for introducing him to the gradient sensing mechanism of Dictyostelium, and to Peter Devreotes and his lab members, who welcomed him into their lab and answer all questions, no matter how trivial. The assistance of Brett Kutscher with the figures, and Lan Ma, Janet Effler and J. Krishnan for providing helpful comments on the manusc ript are all gratefully acknowledged. This work was s upported in part by the Whitaker Foundation and the National Science Foundation's Biocomplexity program, through grant number DMS-0083500.",
year = "2003",
doi = "10.3166/ejc.9.227-236",
language = "English (US)",
volume = "9",
pages = "227--236",
journal = "European Journal of Control",
issn = "0947-3580",
publisher = "Lavoisier",
number = "2-3",
}