Feature-based fusion of medical imaging data

Vince D. Calhoun, Tülay Adali

Research output: Contribution to journalArticlepeer-review

145 Scopus citations


The acquisition of multiple brain imaging types for a given study is a very common practice. There have been a number of approaches proposed for combining or fusing multitask or multimodal information. These can be roughly divided into those that attempt to study convergence of multimodal imaging, for example, how function and structure are related in the same region of the brain, and those that attempt to study the complementary nature of modalities, for example, utilizing temporal EEG information and spatial functional magnetic resonance imaging information. Within each of these categories, one can attempt data integration (the use of one imaging modality to improve the results of another) or true data fusion (in which multiple modalities are utilized to inform one another). We review both approaches and present a recent computational approach that first preprocesses the data to compute features of interest. The features are then analyzed in a multivariate manner using independent component analysis. We describe the approach in detail and provide examples of how it has been used for different fusion tasks. We also propose a method for selecting which combination of modalities provides the greatest value in discriminating groups. Finally, we summarize and describe future research topics.

Original languageEnglish (US)
Pages (from-to)711-720
Number of pages10
JournalIEEE Transactions on Information Technology in Biomedicine
Issue number5
StatePublished - 2009
Externally publishedYes


  • Data fusion
  • EEG
  • Functional magnetic resonance imaging (fMRI)
  • Independent component analysis (ICA)
  • Multivariate data analysis

ASJC Scopus subject areas

  • Biotechnology
  • Computer Science Applications
  • Electrical and Electronic Engineering


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