Feasibility of a modified cone-beam CT rotation trajectory to improve liver periphery visualization during transarterial chemoembolization1

Rüdiger E. Schernthaner, Julius Chapiro, Sonia Sahu, Paul Withagen, Rafael Duran, Jae Ho Sohn, Alessandro Radaelli, Imramsjah Martin Van Der Bom, Jean François H. Geschwind, Mingde Lin

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Purpose: To compare liver coverage and tumor detectability by using preprocedural magnetic resonance (MR) images as a reference, as well as radiation exposure of cone-beam computed tomography (CT) with different rotational trajectories. Materials and Methods: Fifteen patients (nine men and six women; mean age 6 standard deviation, 65 years 6 5) with primary or secondary liver cancer were retrospectively included in this institutional review board-approved study. A modified conebeam CT protocol was used in which the C-arm rotates from +55° to 2185° (open arc cone-beam CT) instead of 2120° to +120° (closed arc cone-beam CT). Each patient underwent two sessions of transarterial chemoembolization between February 2013 and March 2014 with closed arc and open arc cone-beam CT (during the first and second transarterial chemoembolization sessions, respectively, as part of the institutional transarterial chemoembolization protocol). For each cone-beam CT examination, liver volume and tumor detectability were assessed by using MR images as the reference. Radiation exposure was compared by means of a phantom study. For statistical analysis, paired t tests and a Wilcoxon signed rank test were performed. Results: Mean liver volume imaged was 1695 cm3 6 542 and 1857 cm3 6 571 at closed arc and open arc cone-beam CT, respectively. The coverage of open arc cone-beam CT was significantly higher compared with closed arc cone-beam CT (97% vs 86% of the MR imaging liver volume, P = .002). In eight patients (53%), tumors were partially or completely outside the closed arc cone-beam CT field of view. All tumors were within the open arc cone-beam CT field of view. The open arc cone-beam CT radiation exposure by means of weighted CT index was slightly lower compared with that of closed arc cone-beam CT (25.1%). Conclusion: Open arc cone-beam CT allowed for a significantly improved intraprocedural depiction of peripheral hepatic tumors while achieving a slight radiation exposure reduction.

Original languageEnglish (US)
Pages (from-to)833-841
Number of pages9
Issue number3
StatePublished - Dec 2015

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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