Fatty Acid Oxidation in Cell Fate Determination

Jianhua Xiong

doi:10.1016/j.tibs.2018.04.006

Fatty Acid Oxidation in Cell Fate Determination

Jianhua Xiong

Research output: Contribution to journal › Short survey › peer-review

Abstract

Mitochondrial fatty acid β-oxidation (FAO) is a major catabolic process that degrades long-chain fatty acids. Recent reports reveal a broad role for FAO in cell fate control in endothelial cells, immune cells, and cancer cells. Concurrently, unique molecular pathways influenced by FAO have been identified that alter cell fate decisions.

Original language	English (US)
Pages (from-to)	854-857
Number of pages	4
Journal	Trends in biochemical sciences
Volume	43
Issue number	11
DOIs	https://doi.org/10.1016/j.tibs.2018.04.006
State	Published - Nov 2018
Externally published	Yes

Keywords

acetylation
cancer
endothelial cell
immune cell
metabolism
mitochondrion

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/j.tibs.2018.04.006

Cite this

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title = "Fatty Acid Oxidation in Cell Fate Determination",

abstract = "Mitochondrial fatty acid β-oxidation (FAO) is a major catabolic process that degrades long-chain fatty acids. Recent reports reveal a broad role for FAO in cell fate control in endothelial cells, immune cells, and cancer cells. Concurrently, unique molecular pathways influenced by FAO have been identified that alter cell fate decisions.",

keywords = "acetylation, cancer, endothelial cell, immune cell, metabolism, mitochondrion",

author = "Jianhua Xiong",

note = "Funding Information: The author sincerely apologizes to colleagues whose work could not be included due to space limitations. The author is grateful for the support from the National Institutes of Health (NIH) Intramural Program and the Leducq Foundation. The author thanks the NIH Fellows Editorial Board and Douglas Joubert, NIH Library Writing Center, for manuscript editing assistance. Publisher Copyright: {\textcopyright} 2018",

year = "2018",

month = nov,

doi = "10.1016/j.tibs.2018.04.006",

language = "English (US)",

volume = "43",

pages = "854--857",

journal = "Trends in biochemical sciences",

issn = "0968-0004",

publisher = "Elsevier Limited",

number = "11",

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TY - JOUR

T1 - Fatty Acid Oxidation in Cell Fate Determination

AU - Xiong, Jianhua

N1 - Funding Information: The author sincerely apologizes to colleagues whose work could not be included due to space limitations. The author is grateful for the support from the National Institutes of Health (NIH) Intramural Program and the Leducq Foundation. The author thanks the NIH Fellows Editorial Board and Douglas Joubert, NIH Library Writing Center, for manuscript editing assistance. Publisher Copyright: © 2018

PY - 2018/11

Y1 - 2018/11

N2 - Mitochondrial fatty acid β-oxidation (FAO) is a major catabolic process that degrades long-chain fatty acids. Recent reports reveal a broad role for FAO in cell fate control in endothelial cells, immune cells, and cancer cells. Concurrently, unique molecular pathways influenced by FAO have been identified that alter cell fate decisions.

AB - Mitochondrial fatty acid β-oxidation (FAO) is a major catabolic process that degrades long-chain fatty acids. Recent reports reveal a broad role for FAO in cell fate control in endothelial cells, immune cells, and cancer cells. Concurrently, unique molecular pathways influenced by FAO have been identified that alter cell fate decisions.

KW - acetylation

KW - cancer

KW - endothelial cell

KW - immune cell

KW - metabolism

KW - mitochondrion

UR - http://www.scopus.com/inward/record.url?scp=85046671226&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046671226&partnerID=8YFLogxK

U2 - 10.1016/j.tibs.2018.04.006

DO - 10.1016/j.tibs.2018.04.006

M3 - Short survey

C2 - 29735398

AN - SCOPUS:85046671226

SN - 0968-0004

VL - 43

SP - 854

EP - 857

JO - Trends in biochemical sciences

JF - Trends in biochemical sciences

IS - 11

ER -

Fatty Acid Oxidation in Cell Fate Determination

Abstract

Keywords

ASJC Scopus subject areas

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