TY - JOUR
T1 - Fate of nigrostriatal neurons in young mature mice given 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
T2 - A neurochemical and morphological reassessment
AU - Ricaurte, George A.
AU - William Langston, J.
AU - Delanney, Louise E.
AU - Irwin, Ian
AU - Peroutka, Stephen J.
AU - Forno, Lysia S.
N1 - Funding Information:
The authors wish to thank Edna McVey-Casem and ZoAnn McBride for assistance in manuscript preparation and Lincoln Tom and Ruth Grajcer for technical assistance. This work was supported in part by the United Parkinson Foundation, the Retirement Research Foundation, the Institute for Medical Research, Santa Clara Valley Medical Center, the Veterans Administration Medical Research Program, the Pimley Research Fund at Stanford University School of Medicine, and NIEHS Grant 1 R01 ES03697-01.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1986/6/18
Y1 - 1986/6/18
N2 - The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on nigrostriatal dopaminergic neurons in the mouse was re-examined in view of recent conflicting reports regarding the neurotoxic effect of MPTP in this experimental animal. It was found that while MPTP destroyed a substantial number of dopaminergic nerve terminals in the striatum of young mature (6-8 weeks old) mice, it left the majority of cells in the pars compacta of the substantia nigra (SNc) unaffected. It was also found that 5 months after MPTP treatment there was substantial, although incomplete, recovery of striatal DA nerve terminal markers (DA level, metabolites, uptake, [3H]mazindol binding). Given these observations, it is concluded that while the young mature MPTP mouse may not be a valid animal model of Parkinson's disease (since it does not develop severe SNc cell loss characteristic of this disorder), it will be valuable for the study of how MPTP destroys dopaminergic nerve terminals and may prove useful as an experimental system for studying recovery of dopaminergic fibers after injury and for exploring ways to accelerate this recovery.
AB - The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on nigrostriatal dopaminergic neurons in the mouse was re-examined in view of recent conflicting reports regarding the neurotoxic effect of MPTP in this experimental animal. It was found that while MPTP destroyed a substantial number of dopaminergic nerve terminals in the striatum of young mature (6-8 weeks old) mice, it left the majority of cells in the pars compacta of the substantia nigra (SNc) unaffected. It was also found that 5 months after MPTP treatment there was substantial, although incomplete, recovery of striatal DA nerve terminal markers (DA level, metabolites, uptake, [3H]mazindol binding). Given these observations, it is concluded that while the young mature MPTP mouse may not be a valid animal model of Parkinson's disease (since it does not develop severe SNc cell loss characteristic of this disorder), it will be valuable for the study of how MPTP destroys dopaminergic nerve terminals and may prove useful as an experimental system for studying recovery of dopaminergic fibers after injury and for exploring ways to accelerate this recovery.
KW - Parkinson's disease
KW - dopamine
KW - neurotoxicity
KW - striatum
KW - substantia nigra
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U2 - 10.1016/0006-8993(86)90905-4
DO - 10.1016/0006-8993(86)90905-4
M3 - Article
C2 - 3487376
AN - SCOPUS:0022477535
SN - 0006-8993
VL - 376
SP - 117
EP - 124
JO - Brain Research
JF - Brain Research
IS - 1
ER -