Fatal Seronegative Ehrlichiosis in a Patient with HIV Infection

Christopher D. Paddock, David P. Suchard, Kevin L. Grumbach, W. Keith Hadley, Russell L. Kerschmann, Nancy W. Abbey, Jaqueline E. Dawson, Burt E. Anderson, Kimetha G. Sims, J. Stephen Dumler, Brian G. Herndier

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


Human infection with Ehrlichia chaffeensis, a recently identified bacterium included in the family Rickettsiaceae,1,2 results in an acute, generally self-limited, febrile illness associated with cytopenia and hepatic-enzyme abnormalities. Several hundred cases of E. chaffeensis infection have been recognized since 1986, although ehrlichiosis has not been described in patients infected with the human immunodeficiency virus (HIV). We report the course of a fatal seronegative ehrlichial infection in a woman with advanced HIV infection. The infection was diagnosed by light and electron microscopy, immunohistochemical techniques, and the polymerase chain reaction. The potential for successful antimicrobial treatment, combined with the possible absence…

Original languageEnglish (US)
Pages (from-to)1164-1167
Number of pages4
JournalNew England Journal of Medicine
Issue number16
StatePublished - Oct 14 1993

ASJC Scopus subject areas

  • Medicine(all)


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