Fatal pancarditis associated with human granulocytic ehrlichiosis in a 44-year-old man

Arshad Jahangir; Chris Kolbert; William Edwards; Paul Mitchell; J. Stephen Dumler; David H. Persing

doi:10.1086/515014

Fatal pancarditis associated with human granulocytic ehrlichiosis in a 44-year-old man

Arshad Jahangir, Chris Kolbert, William Edwards, Paul Mitchell, J. Stephen Dumler, David H. Persing

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41 Scopus citations

Abstract

Human cases of infection with a granulocytotropic Ehrlichia species closely related to Ehrlichia equi are now being described with increasing frequency in the United States, especially in areas where Lyme disease is already endemic. We describe a case of fatal pancarditis during the course of human granulocytic ehrlichiosis (HGE) in a 44-year-old outdoor worker who was previously treated for presumptive Lyme disease. Serological and molecular diagnostic tests for Borrelia burgdorferi and Babesia microti infections were negative. Postmortem serum specimens were seroreactive for HGE, and molecular evidence of infection with the HGE agent was obtained. These findings suggest that carditis may be a manifestation of HGE, further complicating the differential diagnosis of tick-borne illness.

Original language	English (US)
Pages (from-to)	1424-1427
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	27
Issue number	6
DOIs	https://doi.org/10.1086/515014
State	Published - Dec 1998
Externally published	Yes

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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title = "Fatal pancarditis associated with human granulocytic ehrlichiosis in a 44-year-old man",

abstract = "Human cases of infection with a granulocytotropic Ehrlichia species closely related to Ehrlichia equi are now being described with increasing frequency in the United States, especially in areas where Lyme disease is already endemic. We describe a case of fatal pancarditis during the course of human granulocytic ehrlichiosis (HGE) in a 44-year-old outdoor worker who was previously treated for presumptive Lyme disease. Serological and molecular diagnostic tests for Borrelia burgdorferi and Babesia microti infections were negative. Postmortem serum specimens were seroreactive for HGE, and molecular evidence of infection with the HGE agent was obtained. These findings suggest that carditis may be a manifestation of HGE, further complicating the differential diagnosis of tick-borne illness.",

author = "Arshad Jahangir and Chris Kolbert and William Edwards and Paul Mitchell and Dumler, {J. Stephen} and Persing, {David H.}",

note = "Funding Information: Received 29 August 1997; revised 24 July 1998. Financial support: D.H.P. was supported in part by the National Institutes of Health (U.S. Public Health Service grants AI32403, AI45253, and AI41103) and the Centers for Disease Control and Prevention (cooperative agreements U50/CCU510343 and U50/CCU510528). Reprints or correspondence: Dr. David H. Persing, Mayo Clinic, 200 First Street Southwest, Guggenheim 501, Rochester, Minnesota 55905.",

year = "1998",

month = dec,

doi = "10.1086/515014",

language = "English (US)",

volume = "27",

pages = "1424--1427",

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issn = "1058-4838",

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T1 - Fatal pancarditis associated with human granulocytic ehrlichiosis in a 44-year-old man

AU - Jahangir, Arshad

AU - Kolbert, Chris

AU - Edwards, William

AU - Mitchell, Paul

AU - Dumler, J. Stephen

AU - Persing, David H.

N1 - Funding Information: Received 29 August 1997; revised 24 July 1998. Financial support: D.H.P. was supported in part by the National Institutes of Health (U.S. Public Health Service grants AI32403, AI45253, and AI41103) and the Centers for Disease Control and Prevention (cooperative agreements U50/CCU510343 and U50/CCU510528). Reprints or correspondence: Dr. David H. Persing, Mayo Clinic, 200 First Street Southwest, Guggenheim 501, Rochester, Minnesota 55905.

PY - 1998/12

Y1 - 1998/12

N2 - Human cases of infection with a granulocytotropic Ehrlichia species closely related to Ehrlichia equi are now being described with increasing frequency in the United States, especially in areas where Lyme disease is already endemic. We describe a case of fatal pancarditis during the course of human granulocytic ehrlichiosis (HGE) in a 44-year-old outdoor worker who was previously treated for presumptive Lyme disease. Serological and molecular diagnostic tests for Borrelia burgdorferi and Babesia microti infections were negative. Postmortem serum specimens were seroreactive for HGE, and molecular evidence of infection with the HGE agent was obtained. These findings suggest that carditis may be a manifestation of HGE, further complicating the differential diagnosis of tick-borne illness.

AB - Human cases of infection with a granulocytotropic Ehrlichia species closely related to Ehrlichia equi are now being described with increasing frequency in the United States, especially in areas where Lyme disease is already endemic. We describe a case of fatal pancarditis during the course of human granulocytic ehrlichiosis (HGE) in a 44-year-old outdoor worker who was previously treated for presumptive Lyme disease. Serological and molecular diagnostic tests for Borrelia burgdorferi and Babesia microti infections were negative. Postmortem serum specimens were seroreactive for HGE, and molecular evidence of infection with the HGE agent was obtained. These findings suggest that carditis may be a manifestation of HGE, further complicating the differential diagnosis of tick-borne illness.

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Fatal pancarditis associated with human granulocytic ehrlichiosis in a 44-year-old man

Abstract

ASJC Scopus subject areas

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