Fat flies expanded the hippo pathway: a matter of size control.

Feng Yin, Duojia Pan

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


By simultaneously inhibiting cell proliferation while promoting apoptosis, the Hippo signaling pathway provides a robust mechanism to restrict organ size during Drosophila development. Despite impressive progress in revealing the key intracellular components of this growth-regulatory pathway, the nature of the signal that regulates Hippo signaling in vivo has remained elusive. Several studies now implicate the atypical cadherin protein Fat as a cell surface receptor for the Hippo signaling pathway, thus potentially linking the Hippo kinase cascade with the extracellular milieu.

Original languageEnglish (US)
JournalScience's STKE : signal transduction knowledge environment
Issue number380
StatePublished - Apr 21 2007

ASJC Scopus subject areas

  • Medicine(all)


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