TY - JOUR
T1 - Fasting
T2 - Molecular mechanisms and clinical applications
AU - Longo, Valter D.
AU - Mattson, Mark P.
PY - 2014/2/4
Y1 - 2014/2/4
N2 - Fasting has been practiced for millennia, but, only recently, studies have shed light on its role in adaptive cellular responses that reduce oxidative damage and inflammation, optimize energy metabolism, and bolster cellular protection. In lower eukaryotes, chronic fasting extends longevity, in part, by reprogramming metabolic and stress resistance pathways. In rodents intermittent or periodic fasting protects against diabetes, cancers, heart disease, and neurodegeneration, while in humans it helps reduce obesity, hypertension, asthma, and rheumatoid arthritis. Thus, fasting has the potential to delay aging and help prevent and treat diseases while minimizing the side effects caused by chronic dietary interventions.
AB - Fasting has been practiced for millennia, but, only recently, studies have shed light on its role in adaptive cellular responses that reduce oxidative damage and inflammation, optimize energy metabolism, and bolster cellular protection. In lower eukaryotes, chronic fasting extends longevity, in part, by reprogramming metabolic and stress resistance pathways. In rodents intermittent or periodic fasting protects against diabetes, cancers, heart disease, and neurodegeneration, while in humans it helps reduce obesity, hypertension, asthma, and rheumatoid arthritis. Thus, fasting has the potential to delay aging and help prevent and treat diseases while minimizing the side effects caused by chronic dietary interventions.
UR - http://www.scopus.com/inward/record.url?scp=84893802111&partnerID=8YFLogxK
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U2 - 10.1016/j.cmet.2013.12.008
DO - 10.1016/j.cmet.2013.12.008
M3 - Article
C2 - 24440038
AN - SCOPUS:84893802111
SN - 1550-4131
VL - 19
SP - 181
EP - 192
JO - Cell Metabolism
JF - Cell Metabolism
IS - 2
ER -