Fasting Mimicking Diets Reverse Accelerated Biological Aging in Multiple Sclerosis

Fatemeh Siavoshi; Matthew D. Smith; Sandra Cassard; G. Brett Moreau; J. Nicholas Brenton; Ellen M. Mowry; Kathryn C. Fitzgerald; Pavan Bhargava

doi:10.1002/ana.78044

Fasting Mimicking Diets Reverse Accelerated Biological Aging in Multiple Sclerosis

Fatemeh Siavoshi
, Matthew D. Smith
, Sandra Cassard
, G. Brett Moreau
, J. Nicholas Brenton
, Ellen M. Mowry
, Kathryn C. Fitzgerald
, Pavan Bhargava

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Reversing the aging process may yield significant benefits in people with multiple sclerosis (PwMS), as accelerated biological aging is observed in this population. Secondary analyses of 2 previously conducted dietary interventions including a 6-month modified ketogenic diet in 39 participants and an 8-week randomized comparison of intermittent and daily calorie restriction versus a weight-stable regimen in 36 participants demonstrated significant decreases in metabolomic age (mAge) following the ketogenic diet (p = 0.009) and intermittent calorie restriction (p = 0.04), whereas daily calorie reduction had no effect. These findings indicate that fasting-mimicking diets (FMDs) can reverse accelerated metabolomic aging in PwMS. ANN NEUROL 2025;98:1278–1282.

Original language	English (US)
Pages (from-to)	1278-1282
Number of pages	5
Journal	Annals of neurology
Volume	98
Issue number	6
DOIs	https://doi.org/10.1002/ana.78044
State	Published - Dec 2025

ASJC Scopus subject areas

Neurology
Clinical Neurology

Access to Document

10.1002/ana.78044

Cite this

@article{d0525d2df55841ad872ce0b83bbabb1e,

title = "Fasting Mimicking Diets Reverse Accelerated Biological Aging in Multiple Sclerosis",

abstract = "Reversing the aging process may yield significant benefits in people with multiple sclerosis (PwMS), as accelerated biological aging is observed in this population. Secondary analyses of 2 previously conducted dietary interventions including a 6-month modified ketogenic diet in 39 participants and an 8-week randomized comparison of intermittent and daily calorie restriction versus a weight-stable regimen in 36 participants demonstrated significant decreases in metabolomic age (mAge) following the ketogenic diet (p = 0.009) and intermittent calorie restriction (p = 0.04), whereas daily calorie reduction had no effect. These findings indicate that fasting-mimicking diets (FMDs) can reverse accelerated metabolomic aging in PwMS. ANN NEUROL 2025;98:1278{\textendash}1282.",

author = "Fatemeh Siavoshi and Smith, \{Matthew D.\} and Sandra Cassard and Moreau, \{G. Brett\} and Brenton, \{J. Nicholas\} and Mowry, \{Ellen M.\} and Fitzgerald, \{Kathryn C.\} and Pavan Bhargava",

note = "Publisher Copyright: {\textcopyright} 2025 American Neurological Association.",

year = "2025",

month = dec,

doi = "10.1002/ana.78044",

language = "English (US)",

volume = "98",

pages = "1278--1282",

journal = "Annals of neurology",

issn = "0364-5134",

publisher = "John Wiley \& Sons Inc.",

number = "6",

}

TY - JOUR

T1 - Fasting Mimicking Diets Reverse Accelerated Biological Aging in Multiple Sclerosis

AU - Siavoshi, Fatemeh

AU - Smith, Matthew D.

AU - Cassard, Sandra

AU - Moreau, G. Brett

AU - Brenton, J. Nicholas

AU - Mowry, Ellen M.

AU - Fitzgerald, Kathryn C.

AU - Bhargava, Pavan

PY - 2025/12

Y1 - 2025/12

N2 - Reversing the aging process may yield significant benefits in people with multiple sclerosis (PwMS), as accelerated biological aging is observed in this population. Secondary analyses of 2 previously conducted dietary interventions including a 6-month modified ketogenic diet in 39 participants and an 8-week randomized comparison of intermittent and daily calorie restriction versus a weight-stable regimen in 36 participants demonstrated significant decreases in metabolomic age (mAge) following the ketogenic diet (p = 0.009) and intermittent calorie restriction (p = 0.04), whereas daily calorie reduction had no effect. These findings indicate that fasting-mimicking diets (FMDs) can reverse accelerated metabolomic aging in PwMS. ANN NEUROL 2025;98:1278–1282.

AB - Reversing the aging process may yield significant benefits in people with multiple sclerosis (PwMS), as accelerated biological aging is observed in this population. Secondary analyses of 2 previously conducted dietary interventions including a 6-month modified ketogenic diet in 39 participants and an 8-week randomized comparison of intermittent and daily calorie restriction versus a weight-stable regimen in 36 participants demonstrated significant decreases in metabolomic age (mAge) following the ketogenic diet (p = 0.009) and intermittent calorie restriction (p = 0.04), whereas daily calorie reduction had no effect. These findings indicate that fasting-mimicking diets (FMDs) can reverse accelerated metabolomic aging in PwMS. ANN NEUROL 2025;98:1278–1282.

UR - https://www.scopus.com/pages/publications/105016717247

UR - https://www.scopus.com/pages/publications/105016717247#tab=citedBy

U2 - 10.1002/ana.78044

DO - 10.1002/ana.78044

M3 - Article

C2 - 40970462

AN - SCOPUS:105016717247

SN - 0364-5134

VL - 98

SP - 1278

EP - 1282

JO - Annals of neurology

JF - Annals of neurology

IS - 6

ER -

Fasting Mimicking Diets Reverse Accelerated Biological Aging in Multiple Sclerosis

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this