Fast tracking of cardiac motion using 3D-HARP

Li Pan, Jerry L. Prince, João A.C. Lima, Nael F. Osman

Research output: Contribution to journalArticlepeer-review

94 Scopus citations


Magnetic resonance (MR) tagging is capable of accurate, noninvasive quantification of regional myocardial function. Routine clinical use, however, is hindered by cumbersome and time-consuming postprocessing procedures. We propose a fast, semiautomatic method for tracking three-dimensional (3-D) cardiac motion from a temporal sequence of short- and long-axis tagged MR images. The new method, called 3-D-HARmonic Phase (3D-HARP), extends the HARP approach, previously described for two-dimensional (2-D) tag analysis, to 3-D. A 3-D material mesh model is built to represent a collection of material points inside the left ventricle (LV) wall at a reference time. Harmonic phase, a material property that is time-invariant, is used to track the motion of the mesh through a cardiac cycle. Various motion-related functional properties of the myocardium, such as circumferential strain and left ventricular twist, are computed from the tracked mesh. The correlation analysis of 3D-HARP and FINDTAGS + Tag Strain(E) Analysis (TEA), which are well-established tag analysis techniques, shows that the regression coefficients of circumferential strain (E CC) and twist angle are r 2 = 0.8605 and r 2 = 0.8645, respectively. The total time required for tracking 3-D cardiac motion is approximately 10 min in a 9 timeframe tagged MRI dataset and has the potential to be much faster.

Original languageEnglish (US)
Pages (from-to)1425-1435
Number of pages11
JournalIEEE Transactions on Biomedical Engineering
Issue number8
StatePublished - Aug 2005


  • 3-D-HARmonic Phase (3D-HARP)
  • Cardiac motion tracking
  • MR tagging
  • Phase time-invariance
  • Strain computation

ASJC Scopus subject areas

  • Biomedical Engineering


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