TY - JOUR
T1 - Fast method for brain image segmentation
T2 - Application to proton magnetic resonance spectroscopic imaging
AU - Bonekamp, David
AU - Horská, Alena
AU - Jacobs, Michael A.
AU - Arslanoglu, Atilla
AU - Barker, Peter B.
PY - 2005/11
Y1 - 2005/11
N2 - The interpretation of brain metabolite concentrations measured by quantitative proton magnetic resonance spectroscopic imaging (MRSI) is assisted by knowledge of the percentage of gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) within each MRSI voxel. Usually, this information is determined from T1-weighted magnetic resonance images (MRI) that have a much higher spatial resolution than the MRSI data. While this approach works well, it is time-consuming. In this article, a rapid data acquisition and analysis procedure for image segmentation is described, which is based on collection of several, thick slice, fast spin echo images (FSE) of different contrast. Tissue segmentation is performed with linear "Eigenimage" filtering and normalization. The method was compared to standard segmentation techniques using high-resolution 3D T1-weighted MRI in five subjects. Excellent correlation between the two techniques was obtained, with voxel-wise regression analysis giving GM: R2 = 0.893 ± 0.098, WM: R 2 = 0.892 ± 0.089, In(CSF): R2 = 0.831 ± 0.082). Test-retest analysis in one individual yielded an excellent agreement of measurements with R2 higher than 0.926 in all three tissue classes. Application of FSE/EI segmentation to a sample proton MRSI dataset yielded results similar to prior publications. It is concluded that FSE imaging in conjunction with Eigenimage analysis is a rapid and reliable way of segmenting brain tissue for application to proton MRSI.
AB - The interpretation of brain metabolite concentrations measured by quantitative proton magnetic resonance spectroscopic imaging (MRSI) is assisted by knowledge of the percentage of gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) within each MRSI voxel. Usually, this information is determined from T1-weighted magnetic resonance images (MRI) that have a much higher spatial resolution than the MRSI data. While this approach works well, it is time-consuming. In this article, a rapid data acquisition and analysis procedure for image segmentation is described, which is based on collection of several, thick slice, fast spin echo images (FSE) of different contrast. Tissue segmentation is performed with linear "Eigenimage" filtering and normalization. The method was compared to standard segmentation techniques using high-resolution 3D T1-weighted MRI in five subjects. Excellent correlation between the two techniques was obtained, with voxel-wise regression analysis giving GM: R2 = 0.893 ± 0.098, WM: R 2 = 0.892 ± 0.089, In(CSF): R2 = 0.831 ± 0.082). Test-retest analysis in one individual yielded an excellent agreement of measurements with R2 higher than 0.926 in all three tissue classes. Application of FSE/EI segmentation to a sample proton MRSI dataset yielded results similar to prior publications. It is concluded that FSE imaging in conjunction with Eigenimage analysis is a rapid and reliable way of segmenting brain tissue for application to proton MRSI.
KW - Brain
KW - Eigenimage filter
KW - Magnetic resonance spectroscopic imaging
KW - Partial volume correction
KW - Tissue class segmentation
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U2 - 10.1002/mrm.20657
DO - 10.1002/mrm.20657
M3 - Article
C2 - 16187272
AN - SCOPUS:27644598162
SN - 0740-3194
VL - 54
SP - 1268
EP - 1272
JO - Magnetic resonance in medicine
JF - Magnetic resonance in medicine
IS - 5
ER -