Fast acquisition of high-resolution 2D NMR spectroscopy in inhomogeneous magnetic fields

Liangjie Lin; Zhiliang Wei; Qing Zeng; Jian Yang; Yanqin Lin; Zhong Chen

doi:10.1016/j.cplett.2016.04.015

Fast acquisition of high-resolution 2D NMR spectroscopy in inhomogeneous magnetic fields

Liangjie Lin, Zhiliang Wei, Qing Zeng, Jian Yang, Yanqin Lin, Zhong Chen

Research output: Contribution to journal › Article › peer-review

Abstract

High-resolution nuclear magnetic resonance (NMR) spectroscopy plays an important role in chemical and biological analyses. In this study, we combine the J-coupling coherence transfer module with the echo-train acquisition technique for fast acquisition of high-resolution 2D NMR spectra in magnetic fields with unknown spatial variations. The proposed method shows satisfactory performance on a 5 mM ethyl 3-bromopropionate sample, under a 5-kHz (10 ppm at 11.7 T) B₀ inhomogeneous field, as well as under varying degrees of pulse-flip-angle deviations. Moreover, a simulative ex situ NMR measurement is also conducted to show the effectiveness of the proposed pulse sequence.

Original language	English (US)
Pages (from-to)	62-67
Number of pages	6
Journal	Chemical Physics Letters
Volume	652
DOIs	https://doi.org/10.1016/j.cplett.2016.04.015
State	Published - May 16 2016
Externally published	Yes

Keywords

Echo train acquisition
High-resolution
Inhomogeneous fields
NMR
Scalar-coupling coherence transfer

ASJC Scopus subject areas

Physics and Astronomy(all)
Physical and Theoretical Chemistry

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10.1016/j.cplett.2016.04.015

Cite this

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title = "Fast acquisition of high-resolution 2D NMR spectroscopy in inhomogeneous magnetic fields",

abstract = "High-resolution nuclear magnetic resonance (NMR) spectroscopy plays an important role in chemical and biological analyses. In this study, we combine the J-coupling coherence transfer module with the echo-train acquisition technique for fast acquisition of high-resolution 2D NMR spectra in magnetic fields with unknown spatial variations. The proposed method shows satisfactory performance on a 5 mM ethyl 3-bromopropionate sample, under a 5-kHz (10 ppm at 11.7 T) B0 inhomogeneous field, as well as under varying degrees of pulse-flip-angle deviations. Moreover, a simulative ex situ NMR measurement is also conducted to show the effectiveness of the proposed pulse sequence.",

keywords = "Echo train acquisition, High-resolution, Inhomogeneous fields, NMR, Scalar-coupling coherence transfer",

author = "Liangjie Lin and Zhiliang Wei and Qing Zeng and Jian Yang and Yanqin Lin and Zhong Chen",

note = "Funding Information: This work was partially supported by the National Natural Science Foundation of China [Grant Nos. 11105114 , 11375147 ], and the Natural Science Foundation of Fujian Province of China [Grant No. 2014J05012 ]. Publisher Copyright: {\textcopyright} 2016 Elsevier B.V. All rights reserved.",

year = "2016",

month = may,

day = "16",

doi = "10.1016/j.cplett.2016.04.015",

language = "English (US)",

volume = "652",

pages = "62--67",

journal = "Chemical Physics Letters",

issn = "0009-2614",

publisher = "Elsevier",

}

TY - JOUR

T1 - Fast acquisition of high-resolution 2D NMR spectroscopy in inhomogeneous magnetic fields

AU - Lin, Liangjie

AU - Wei, Zhiliang

AU - Zeng, Qing

AU - Yang, Jian

AU - Lin, Yanqin

AU - Chen, Zhong

N1 - Funding Information: This work was partially supported by the National Natural Science Foundation of China [Grant Nos. 11105114 , 11375147 ], and the Natural Science Foundation of Fujian Province of China [Grant No. 2014J05012 ]. Publisher Copyright: © 2016 Elsevier B.V. All rights reserved.

PY - 2016/5/16

Y1 - 2016/5/16

N2 - High-resolution nuclear magnetic resonance (NMR) spectroscopy plays an important role in chemical and biological analyses. In this study, we combine the J-coupling coherence transfer module with the echo-train acquisition technique for fast acquisition of high-resolution 2D NMR spectra in magnetic fields with unknown spatial variations. The proposed method shows satisfactory performance on a 5 mM ethyl 3-bromopropionate sample, under a 5-kHz (10 ppm at 11.7 T) B0 inhomogeneous field, as well as under varying degrees of pulse-flip-angle deviations. Moreover, a simulative ex situ NMR measurement is also conducted to show the effectiveness of the proposed pulse sequence.

AB - High-resolution nuclear magnetic resonance (NMR) spectroscopy plays an important role in chemical and biological analyses. In this study, we combine the J-coupling coherence transfer module with the echo-train acquisition technique for fast acquisition of high-resolution 2D NMR spectra in magnetic fields with unknown spatial variations. The proposed method shows satisfactory performance on a 5 mM ethyl 3-bromopropionate sample, under a 5-kHz (10 ppm at 11.7 T) B0 inhomogeneous field, as well as under varying degrees of pulse-flip-angle deviations. Moreover, a simulative ex situ NMR measurement is also conducted to show the effectiveness of the proposed pulse sequence.

KW - Echo train acquisition

KW - High-resolution

KW - Inhomogeneous fields

KW - NMR

KW - Scalar-coupling coherence transfer

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DO - 10.1016/j.cplett.2016.04.015

M3 - Article

AN - SCOPUS:84964403207

SN - 0009-2614

VL - 652

SP - 62

EP - 67

JO - Chemical Physics Letters

JF - Chemical Physics Letters

ER -

Fast acquisition of high-resolution 2D NMR spectroscopy in inhomogeneous magnetic fields

Abstract

Keywords

ASJC Scopus subject areas

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