Fast 3D functional magnetic resonance imaging at 1.5 T with spiral acquisition

Yihong Yang, Gary H. Glover, Peter Van Gelderen, Venkata S. Mattay, Attanagoda K.S. Santha, Roy H. Sexton, Nick F. Ramsey, Chrit T.W. Moonen, Daniel R. Weinberger, Joseph A. Frank, Jeff H. Duyn

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


A new method to perform rapid 3D fMRI in human brain is introduced and evaluated in normal subjects, on a standard clinical scanner at 1.5 Tesla. The method combines a highly stable gradient echo technique with a spiral scan method, to detect brain activation related changes in blood oxygenation with high sensitivity. A motor activation paradigm with a duration of less than 5 min, performed on 10 subjects, consistently showed significant changes in signal intensity in the area of the motor cortex. In all subjects, these changes survived high statistical thresholds.

Original languageEnglish (US)
Pages (from-to)620-626
Number of pages7
JournalMagnetic resonance in medicine
Issue number4
StatePublished - Oct 1996
Externally publishedYes


  • MRI
  • fMRI
  • motor cortex
  • spiral scanning

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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