TY - JOUR
T1 - Family history of asthma influences outpatient respiratory outcomes in children with BPD
AU - McGlynn, Julianne R.
AU - Aoyama, Brianna C.
AU - Collaco, Joseph M.
AU - McGrath-Morrow, Sharon A.
N1 - Funding Information:
The authors wish to thank the families who participated in this study. Funding sources included the National Institutes of Health, the Johns Hopkins Eudowood Board, the Thomas Wilson Foundation, and the Children's Hospital of Philadelphia. This study was supported by the National Institutes of Health (Bethesda, MD, USA) (SAM: R01 HL114800), the Johns Hopkins Eudowood Foundation (BCA: Fellowship grant), the Children's Hospital of Philadelphia (JMC), and the Thomas Wilson Foundation (JMC). The funding sources had no involvement in the writing of the manuscript or the decision to submit it.
Funding Information:
The authors wish to thank the families who participated in this study. Funding sources included the National Institutes of Health, the Johns Hopkins Eudowood Board, the Thomas Wilson Foundation, and the Children's Hospital of Philadelphia. This study was supported by the National Institutes of Health (Bethesda, MD, USA) (SAM: R01 HL114800), the Johns Hopkins Eudowood Foundation (BCA: Fellowship grant), the Children's Hospital of Philadelphia (JMC), and the Thomas Wilson Foundation (JMC). The funding sources had no involvement in the writing of the manuscript or the decision to submit it.
Publisher Copyright:
© 2021 Wiley Periodicals LLC
PY - 2021/10
Y1 - 2021/10
N2 - Introduction: Preterm children with bronchopulmonary dysplasia (BPD) are at increased risk for intermittent and chronic respiratory symptoms during childhood and adult life. Identifying children at higher risk for respiratory morbidities in the outpatient setting could help improve long-term outcomes. In this study, we hypothesized that a family history of asthma (FHA) is a risk factor for higher acute care usage and respiratory symptoms in preterm infants/children with BPD, following initial discharge home. Methods: Subjects were recruited from the Johns Hopkins Bronchopulmonary Dysplasia outpatient clinic between January 2008 and February 2020 (n = 827). Surveys were administered to caregivers and demographics and clinical characteristics were obtained through chart review. Results: Demographic features associated with FHA included public health insurance, lower median household income, and nonwhite race. Children with FHA had higher odds of emergency department (ED) visits, systemic steroid use, nighttime respiratory symptoms, and activity limitations. There was no association between FHA and BPD severity. Conclusion: This study found that children with BPD and FHA were more likely to have respiratory symptoms and acute care usage during the first 3 years of life and that FHA was associated with lower socioeconomic status. Although there was no association between FHA and BPD severity, FHA could predict an increased likelihood of both ED visits and need for systemic steroids in infants/children with BPD followed in the outpatient setting.
AB - Introduction: Preterm children with bronchopulmonary dysplasia (BPD) are at increased risk for intermittent and chronic respiratory symptoms during childhood and adult life. Identifying children at higher risk for respiratory morbidities in the outpatient setting could help improve long-term outcomes. In this study, we hypothesized that a family history of asthma (FHA) is a risk factor for higher acute care usage and respiratory symptoms in preterm infants/children with BPD, following initial discharge home. Methods: Subjects were recruited from the Johns Hopkins Bronchopulmonary Dysplasia outpatient clinic between January 2008 and February 2020 (n = 827). Surveys were administered to caregivers and demographics and clinical characteristics were obtained through chart review. Results: Demographic features associated with FHA included public health insurance, lower median household income, and nonwhite race. Children with FHA had higher odds of emergency department (ED) visits, systemic steroid use, nighttime respiratory symptoms, and activity limitations. There was no association between FHA and BPD severity. Conclusion: This study found that children with BPD and FHA were more likely to have respiratory symptoms and acute care usage during the first 3 years of life and that FHA was associated with lower socioeconomic status. Although there was no association between FHA and BPD severity, FHA could predict an increased likelihood of both ED visits and need for systemic steroids in infants/children with BPD followed in the outpatient setting.
KW - bronchopulmonary dysplasia
KW - family history of asthma
KW - outpatient
KW - prematurity
KW - respiratory outcomes
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U2 - 10.1002/ppul.25603
DO - 10.1002/ppul.25603
M3 - Article
C2 - 34365734
AN - SCOPUS:85112593043
SN - 8755-6863
VL - 56
SP - 3265
EP - 3272
JO - Pediatric Pulmonology
JF - Pediatric Pulmonology
IS - 10
ER -