Familial prostate cancer and its management

Rashmi Singh, Rosalind A. Eeles, Lisa Cannon-Albright, William Isaacs

Research output: Chapter in Book/Report/Conference proceedingChapter


Prostate cancer (PrCa) is an important public health problem, particularly in Western countries, where it is the most common malignancy among men, who have a lifetime risk of one in ten or more.1 The highest incidence is in the USA and Jamaica. Both incidence and mortality have increased worldwide in the last few decades, even when the expected increase from PrCa screening is taken into account.2 The prevalence of PrCa varies markedly between different ethnic groups, with the highest frequency found in African-Americans and the lowest frequency in the Asian populations.1,3,4 The extent to which this ethnic disparity is attributable to environmental or genetic factors is unknown. One of the strongest risk factors for PrCa identified to date is a family history of disease, suggesting that genetic factors are important.

Original languageEnglish (US)
Title of host publicationGenetic Predisposition to Cancer, Second Edition
PublisherCRC Press
Number of pages13
ISBN (Electronic)9781444114287
ISBN (Print)9780340762547
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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