Familial Pancreatic Cancer

Nicholas J. Roberts; Laura D. Wood

doi:10.1007/978-3-030-53786-9_4

Familial Pancreatic Cancer

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

One important factor influencing pancreatic tumorigenesis is inherited genetic variation. Knowledge of a patient’s underlying susceptibility due to germline variants has become an essential component of care for patients with pancreatic cancer and their families. In this chapter, we review the definition of familial pancreatic cancer and key genes that are known to contribute to germline pancreatic cancer risk, several of which have implications for choosing the most effective chemotherapeutic agents. In addition, we discuss germline alterations in susceptibility genes in patients with sporadic pancreatic cancer as well as screening approaches for patients at high-risk for pancreatic cancer. Despite these advances, the genetic basis for the majority of familial pancreatic cancer remains unknown, and further research is needed to translate discoveries into improved patient care.

Original language	English (US)
Title of host publication	Textbook of Pancreatic Cancer
Subtitle of host publication	Principles and Practice of Surgical Oncology
Publisher	Springer Science+Business Media
Pages	51-61
Number of pages	11
ISBN (Electronic)	9783030537869
ISBN (Print)	9783030537852
DOIs	https://doi.org/10.1007/978-3-030-53786-9_4
State	Published - Jan 1 2021

Keywords

BRCA2
Familial pancreatic cancer
Family history
Inherited cancer risk
Pancreatic cancer

ASJC Scopus subject areas

General Medicine

Access to Document

10.1007/978-3-030-53786-9_4

Cite this

@inbook{34916fc8ae4c454e9482ded0ff53e509,

title = "Familial Pancreatic Cancer",

abstract = "One important factor influencing pancreatic tumorigenesis is inherited genetic variation. Knowledge of a patient{\textquoteright}s underlying susceptibility due to germline variants has become an essential component of care for patients with pancreatic cancer and their families. In this chapter, we review the definition of familial pancreatic cancer and key genes that are known to contribute to germline pancreatic cancer risk, several of which have implications for choosing the most effective chemotherapeutic agents. In addition, we discuss germline alterations in susceptibility genes in patients with sporadic pancreatic cancer as well as screening approaches for patients at high-risk for pancreatic cancer. Despite these advances, the genetic basis for the majority of familial pancreatic cancer remains unknown, and further research is needed to translate discoveries into improved patient care.",

keywords = "BRCA2, Familial pancreatic cancer, Family history, Inherited cancer risk, Pancreatic cancer",

author = "Roberts, \{Nicholas J.\} and Wood, \{Laura D.\}",

note = "Publisher Copyright: {\textcopyright} Springer Nature Switzerland AG 2021 corrected publication 2021",

year = "2021",

month = jan,

day = "1",

doi = "10.1007/978-3-030-53786-9\_4",

language = "English (US)",

isbn = "9783030537852",

pages = "51--61",

booktitle = "Textbook of Pancreatic Cancer",

publisher = "Springer Science+Business Media",

}

TY - CHAP

T1 - Familial Pancreatic Cancer

AU - Roberts, Nicholas J.

AU - Wood, Laura D.

N1 - Publisher Copyright: © Springer Nature Switzerland AG 2021 corrected publication 2021

PY - 2021/1/1

Y1 - 2021/1/1

N2 - One important factor influencing pancreatic tumorigenesis is inherited genetic variation. Knowledge of a patient’s underlying susceptibility due to germline variants has become an essential component of care for patients with pancreatic cancer and their families. In this chapter, we review the definition of familial pancreatic cancer and key genes that are known to contribute to germline pancreatic cancer risk, several of which have implications for choosing the most effective chemotherapeutic agents. In addition, we discuss germline alterations in susceptibility genes in patients with sporadic pancreatic cancer as well as screening approaches for patients at high-risk for pancreatic cancer. Despite these advances, the genetic basis for the majority of familial pancreatic cancer remains unknown, and further research is needed to translate discoveries into improved patient care.

AB - One important factor influencing pancreatic tumorigenesis is inherited genetic variation. Knowledge of a patient’s underlying susceptibility due to germline variants has become an essential component of care for patients with pancreatic cancer and their families. In this chapter, we review the definition of familial pancreatic cancer and key genes that are known to contribute to germline pancreatic cancer risk, several of which have implications for choosing the most effective chemotherapeutic agents. In addition, we discuss germline alterations in susceptibility genes in patients with sporadic pancreatic cancer as well as screening approaches for patients at high-risk for pancreatic cancer. Despite these advances, the genetic basis for the majority of familial pancreatic cancer remains unknown, and further research is needed to translate discoveries into improved patient care.

KW - BRCA2

KW - Familial pancreatic cancer

KW - Family history

KW - Inherited cancer risk

KW - Pancreatic cancer

UR - https://www.scopus.com/pages/publications/105013192335

UR - https://www.scopus.com/pages/publications/105013192335#tab=citedBy

U2 - 10.1007/978-3-030-53786-9_4

DO - 10.1007/978-3-030-53786-9_4

M3 - Chapter

AN - SCOPUS:105013192335

SN - 9783030537852

SP - 51

EP - 61

BT - Textbook of Pancreatic Cancer

PB - Springer Science+Business Media

ER -

Familial Pancreatic Cancer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this