Familial occurrences of a variety of premalignant diseases and uncommon malignant neoplasms

Henry T. Lynch, Anne J. Krush, Gabriel M. Mulcahy, William B. Reed

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


A medical genetic study has been undertaken of a large segment of an inbred Dutch kindred containing more than 2000 members. Noteworthy are occurrences of several hereditary precancerous diseases among the family members. These include two siblings with xeroderma pigmentosum and two siblings from another sibship who manifest a syndrome which may possibly be a variant of Fanconi's aplastic anemia. Four patients had histologically verified testicular malignant neoplasms. Other generally rarely occurring cancers included Wilms' tumor, thymic carcinoma, and astrocytoma. At present there is no satisfactory etiologic explanation for these events in this family. Environmental factors common to the family cannot be excluded. Hereditary factors conditioned strongly by consanguinity may be operating in concert with as yet unknown non‐genetic factors such as an oncogenic virus.

Original languageEnglish (US)
Pages (from-to)1474-1479
Number of pages6
Issue number5
StatePublished - May 1974
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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