False dyssynchrony: Problem with image-based cardiac functional analysis using x-ray computed tomography

Masafumi Kidoh, Zeyang Shen, Yuki Suzuki, Luisa Ciuffo, Hiroshi Ashikaga, Shiu-Kai Fung, Yoshito Otake, Stefan L. Zimmerman, Joao A.C. Lima, Takahiro Higuchi, Okkyun Lee, Yoshinobu Sato, Lewis C. Becker, Elliot K. Fishman, Katsuyuki Taguchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We have developed a digitally synthesized patient which we call "Zach" (Zero millisecond Adjustable Clinical Heart) phantom, which allows for an access to the ground truth and assessment of image-based cardiac functional analysis (CFA) using CT images with clinically realistic settings. The study using Zach phantom revealed a major problem with image-based CFA: "False dyssynchrony." Even though the true motion of wall segments is in synchrony, it may appear to be dyssynchrony with the reconstructed cardiac CT images. It is attributed to how cardiac images are reconstructed and how wall locations are updated over cardiac phases. The presence and the degree of false dyssynchrony may vary from scan-to-scan, which could degrade the accuracy and the repeatability (or precision) of image-based CT-CFA exams.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2017
Subtitle of host publicationPhysics of Medical Imaging
EditorsTaly Gilat Schmidt, Joseph Y. Lo, Thomas G. Flohr
ISBN (Electronic)9781510607095
StatePublished - 2017
EventMedical Imaging 2017: Physics of Medical Imaging - Orlando, United States
Duration: Feb 13 2017Feb 16 2017

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2017: Physics of Medical Imaging
Country/TerritoryUnited States


  • Cardiac function analysis
  • Computed tomography
  • Dyssynchrony

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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