Failure of vasodilator infusion to alter pulmonary diffusing capacity in systemic sclerosis

Craig A. Thurm, Fredrick M. Wigley, William P. Dole, Robert A. Wise

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Purpose: Patients with systemic sclerosis (SSc) do not exhibit a normal increase in the diffusing capacity for carbon monoxide (DLCO) on assuming the supine position. We sought to determine whether a potent prostacyclin derivative and vasodilator, iloprost, would reverse this defect. Patients and Methods: Fourteen patients with SSc were enrolled in a randomized, doubleblind, placebo-controlled study of iloprost. Patients were tested before and during 3 days of Uoprost or placebo infusion with both upright and supine pulmonary function studies. Results: The results of baseline pulmonary function studies including DLCO were not significantly altered by iloprost Furthermore, iloprost did not alter the abnormal postural DLCO response. Conclusion: These results suggest that the pulmonary vascular defects seen in this group of patients are not a consequence of reversible pulmonary vasospasm.

Original languageEnglish (US)
Pages (from-to)547-552
Number of pages6
JournalThe American journal of medicine
Issue number5
StatePublished - May 1991

ASJC Scopus subject areas

  • Medicine(all)


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