Failure of one-day praziquantel treatment in patients with multiple neurocysticercosis lesions

E. Javier Pretell; Héctor H. García; Robert H. Gilman; Herbert Saavedra; Manuel Martinez; S. Rodriguez; C. Padilla; M. Porras; A. E. Gonzalez; M. Verastegui; C. Evans; V. C.W. Tsang

doi:10.1016/S0303-8467(01)00137-8

Failure of one-day praziquantel treatment in patients with multiple neurocysticercosis lesions

E. Javier Pretell, Héctor H. García, Robert H. Gilman, Herbert Saavedra, Manuel Martinez, S. Rodriguez, C. Padilla, M. Porras, A. E. Gonzalez, M. Verastegui, C. Evans, V. C.W. Tsang

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

A recently described one-day regimen of praziquantel (PZQ) therapy for neurocysticercosis (NCC), three doses of 25 mg/k given at 2 h intervals, was applied in eight patients with viable NCC cysts without any evidence of inflammation. Resolution of lesions in computed tomography (CT) was observed in all five patients with a single cyst, whereas all cysts survived in three patients with multiple brain parasites. One-day praziquantel is a good regimen for patients with a single viable brain cysticercus but is poorly effective for multiple cysts.

Original language	English (US)
Article number	968
Pages (from-to)	175-177
Number of pages	3
Journal	Clinical Neurology and Neurosurgery
Volume	103
Issue number	3
DOIs	https://doi.org/10.1016/S0303-8467(01)00137-8
State	Published - 2001

Keywords

Cysticercosis
Neurocysticercosis
Praziquantel
Taenia solium

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.1016/S0303-8467(01)00137-8

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Pretell, E. J., García, H. H., Gilman, R. H., Saavedra, H., Martinez, M., Rodriguez, S., Padilla, C., Porras, M., Gonzalez, A. E., Verastegui, M., Evans, C., & Tsang, V. C. W. (2001). Failure of one-day praziquantel treatment in patients with multiple neurocysticercosis lesions. Clinical Neurology and Neurosurgery, 103(3), 175-177. Article 968. https://doi.org/10.1016/S0303-8467(01)00137-8

Pretell, EJ, García, HH, Gilman, RH, Saavedra, H, Martinez, M, Rodriguez, S, Padilla, C, Porras, M, Gonzalez, AE, Verastegui, M, Evans, C & Tsang, VCW 2001, 'Failure of one-day praziquantel treatment in patients with multiple neurocysticercosis lesions', Clinical Neurology and Neurosurgery, vol. 103, no. 3, 968, pp. 175-177. https://doi.org/10.1016/S0303-8467(01)00137-8

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title = "Failure of one-day praziquantel treatment in patients with multiple neurocysticercosis lesions",

abstract = "A recently described one-day regimen of praziquantel (PZQ) therapy for neurocysticercosis (NCC), three doses of 25 mg/k given at 2 h intervals, was applied in eight patients with viable NCC cysts without any evidence of inflammation. Resolution of lesions in computed tomography (CT) was observed in all five patients with a single cyst, whereas all cysts survived in three patients with multiple brain parasites. One-day praziquantel is a good regimen for patients with a single viable brain cysticercus but is poorly effective for multiple cysts.",

keywords = "Cysticercosis, Neurocysticercosis, Praziquantel, Taenia solium",

author = "Pretell, {E. Javier} and Garc{\'i}a, {H{\'e}ctor H.} and Gilman, {Robert H.} and Herbert Saavedra and Manuel Martinez and S. Rodriguez and C. Padilla and M. Porras and Gonzalez, {A. E.} and M. Verastegui and C. Evans and Tsang, {V. C.W.}",

note = "Funding Information: Partial support was received from grants number FD-R-001107 from the Food and Drug Administration, and U19-A145431 from NIAID/NIH (USA).",

year = "2001",

doi = "10.1016/S0303-8467(01)00137-8",

language = "English (US)",

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pages = "175--177",

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AU - Pretell, E. Javier

AU - García, Héctor H.

AU - Gilman, Robert H.

AU - Saavedra, Herbert

AU - Martinez, Manuel

AU - Rodriguez, S.

AU - Padilla, C.

AU - Porras, M.

AU - Gonzalez, A. E.

AU - Verastegui, M.

AU - Evans, C.

AU - Tsang, V. C.W.

N1 - Funding Information: Partial support was received from grants number FD-R-001107 from the Food and Drug Administration, and U19-A145431 from NIAID/NIH (USA).

PY - 2001

Y1 - 2001

N2 - A recently described one-day regimen of praziquantel (PZQ) therapy for neurocysticercosis (NCC), three doses of 25 mg/k given at 2 h intervals, was applied in eight patients with viable NCC cysts without any evidence of inflammation. Resolution of lesions in computed tomography (CT) was observed in all five patients with a single cyst, whereas all cysts survived in three patients with multiple brain parasites. One-day praziquantel is a good regimen for patients with a single viable brain cysticercus but is poorly effective for multiple cysts.

AB - A recently described one-day regimen of praziquantel (PZQ) therapy for neurocysticercosis (NCC), three doses of 25 mg/k given at 2 h intervals, was applied in eight patients with viable NCC cysts without any evidence of inflammation. Resolution of lesions in computed tomography (CT) was observed in all five patients with a single cyst, whereas all cysts survived in three patients with multiple brain parasites. One-day praziquantel is a good regimen for patients with a single viable brain cysticercus but is poorly effective for multiple cysts.

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KW - Neurocysticercosis

KW - Praziquantel

KW - Taenia solium

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Failure of one-day praziquantel treatment in patients with multiple neurocysticercosis lesions

Abstract

Keywords

ASJC Scopus subject areas

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