Factors influencing the long term functional success rate of human renal allografts

A review of 101 renal allografts treated in similar fashion was carried out utilizing actuarial tables to calculate the incidence of success at intervals following transplantation. This study revealed that renal functional success stabilized at 18 months following surgery at rates of 55% and 34% in related living donor and cadaveric donor recipients respectively. Four groups of patients were distinguished by their clinical course having long-term success rates after having survived the first four months of 100, 84, 50, and 29 per cent. The presence of acute tubular necrosis did not alter prognosis, whereas rejection episodes occurring within the first week, or after the first four months, and persistent proteinuria were associated with a success rate of less than 30%. It is suggested that clinical grouping reflects closely the underlying histocompatibility difference.