Factors influencing susceptibility of Nocardia species to trimethoprim-sulfamethoxazole

J. E. Bennett, A. E. Jennings

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Demonstration of synergism between trimethoprim and sulfamethoxazole against 10 Nocardia isolates was found to be critically dependent upon the isolate, the duration of incubation and the trimethoprim-sulfamethoxazole ratio. Inoculum effect was not significant. The trimethoprim-sulfamethoxazole ratio in the commercial, fixed-dose combination was found to contain too little trimethoprim to be optimal for Nocardia.

Original languageEnglish (US)
Pages (from-to)624-627
Number of pages4
JournalAntimicrobial agents and chemotherapy
Issue number4
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases


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