Factors influencing outcome of prednisone dose reduction in myasthenia gravis

M. A. Miano; T. M. Bosley; T. D. Heiman-Patterson; J. Reed; R. C. Sergott; P. J. Savino; N. J. Schatz

doi:10.1212/wnl.41.6.919

Factors influencing outcome of prednisone dose reduction in myasthenia gravis

M. A. Miano, T. M. Bosley, T. D. Heiman-Patterson, J. Reed, R. C. Sergott, P. J. Savino, N. J. Schatz

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

We reviewed retrospectively 114 prednisone dose reduction attempts in 63 myasthenic patients. Dose reduction was considered successful if a patient remained asymptomatic for more than 1 year on no prednisone or a stable low dose of prednisone. Successful dose reduction attempts were more common in patients taking azathioprine, but thymectomy did not influence taper outcome. Slower rate of dose reduction and higher ending dose of prednisone improved the chance of success.

Original language	English (US)
Pages (from-to)	919-921
Number of pages	3
Journal	Neurology
Volume	41
Issue number	6
DOIs	https://doi.org/10.1212/wnl.41.6.919
State	Published - Jun 1991
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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AU - Bosley, T. M.

AU - Heiman-Patterson, T. D.

AU - Reed, J.

AU - Sergott, R. C.

AU - Savino, P. J.

AU - Schatz, N. J.

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AB - We reviewed retrospectively 114 prednisone dose reduction attempts in 63 myasthenic patients. Dose reduction was considered successful if a patient remained asymptomatic for more than 1 year on no prednisone or a stable low dose of prednisone. Successful dose reduction attempts were more common in patients taking azathioprine, but thymectomy did not influence taper outcome. Slower rate of dose reduction and higher ending dose of prednisone improved the chance of success.

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Factors influencing outcome of prednisone dose reduction in myasthenia gravis

Abstract

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