Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil

Ricardo R. Oliveira; Joanemile P. Figueiredo; Luciana S. Cardoso; Rafael L. Jabar; Robson P. Souza; Martin T. Wells; Edgar M. Carvalho; Daniel W. Fitzgerald; Kathleen C. Barnes; Maria Ilma Araújo; Marshall J. Glesby

doi:10.4269/ajtmh.2012.11-0204

Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil

Ricardo R. Oliveira, Joanemile P. Figueiredo, Luciana S. Cardoso, Rafael L. Jabar, Robson P. Souza, Martin T. Wells, Edgar M. Carvalho, Daniel W. Fitzgerald, Kathleen C. Barnes, Maria Ilma Araújo, Marshall J. Glesby

School of Medicine

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Detailed knowledge of factors associated with resistance to Schistosoma mansoni infection in endemic areas might facilitate more effective schistosomiasis control. We conducted a cross-sectional study of persons resistant to schistosomiasis and found no association between socioeconomic status and resistance to infection. Mononuclear cells of resistant subjects produced higher levels of interleukin-5 (IL-5), IL-13 and interferon-γ upon stimulation with soluble egg antigen (SEA) compared with infected persons. When stimulated with Sm21.6 or Sm22.6, levels of IL-10 were higher in cell culture of resistant persons. Levels of IgE against soluble adult wormantigen (SWAP) and against interleukin- 4-inducing principle from S. mansoni eggs (IPSE) and levels of IgG4 against SWAP, SEA, and Sm22.6 were lower in the resistant group compared with the susceptible group. Our data suggest that socioeconomic status could not fully explain resistance to S. mansoni infection observed in the studied area. However, a mixture of Th1 and Th2 immune responses and low levels of specific IgG4 against parasite antigens could be mediating resistance to infection.

Original language	English (US)
Pages (from-to)	296-305
Number of pages	10
Journal	American Journal of Tropical Medicine and Hygiene
Volume	86
Issue number	2
DOIs	https://doi.org/10.4269/ajtmh.2012.11-0204
State	Published - Feb 2012

ASJC Scopus subject areas

Parasitology
Infectious Diseases
Virology

Access to Document

10.4269/ajtmh.2012.11-0204

Cite this

Oliveira, R. R., Figueiredo, J. P., Cardoso, L. S., Jabar, R. L., Souza, R. P., Wells, M. T., Carvalho, E. M., Fitzgerald, D. W., Barnes, K. C., Araújo, M. I., & Glesby, M. J. (2012). Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil. American Journal of Tropical Medicine and Hygiene, 86(2), 296-305. https://doi.org/10.4269/ajtmh.2012.11-0204

Oliveira, RR, Figueiredo, JP, Cardoso, LS, Jabar, RL, Souza, RP, Wells, MT, Carvalho, EM, Fitzgerald, DW, Barnes, KC, Araújo, MI & Glesby, MJ 2012, 'Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil', American Journal of Tropical Medicine and Hygiene, vol. 86, no. 2, pp. 296-305. https://doi.org/10.4269/ajtmh.2012.11-0204

@article{e7faad07e5d84a08acf5ea27e603fda2,

title = "Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil",

abstract = "Detailed knowledge of factors associated with resistance to Schistosoma mansoni infection in endemic areas might facilitate more effective schistosomiasis control. We conducted a cross-sectional study of persons resistant to schistosomiasis and found no association between socioeconomic status and resistance to infection. Mononuclear cells of resistant subjects produced higher levels of interleukin-5 (IL-5), IL-13 and interferon-γ upon stimulation with soluble egg antigen (SEA) compared with infected persons. When stimulated with Sm21.6 or Sm22.6, levels of IL-10 were higher in cell culture of resistant persons. Levels of IgE against soluble adult wormantigen (SWAP) and against interleukin- 4-inducing principle from S. mansoni eggs (IPSE) and levels of IgG4 against SWAP, SEA, and Sm22.6 were lower in the resistant group compared with the susceptible group. Our data suggest that socioeconomic status could not fully explain resistance to S. mansoni infection observed in the studied area. However, a mixture of Th1 and Th2 immune responses and low levels of specific IgG4 against parasite antigens could be mediating resistance to infection.",

author = "Oliveira, {Ricardo R.} and Figueiredo, {Joanemile P.} and Cardoso, {Luciana S.} and Jabar, {Rafael L.} and Souza, {Robson P.} and Wells, {Martin T.} and Carvalho, {Edgar M.} and Fitzgerald, {Daniel W.} and Barnes, {Kathleen C.} and Ara{\'u}jo, {Maria Ilma} and Glesby, {Marshall J.}",

year = "2012",

month = feb,

doi = "10.4269/ajtmh.2012.11-0204",

language = "English (US)",

volume = "86",

pages = "296--305",

journal = "American Journal of Tropical Medicine and Hygiene",

issn = "0002-9637",

publisher = "American Society of Tropical Medicine and Hygiene",

number = "2",

}

TY - JOUR

T1 - Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil

AU - Oliveira, Ricardo R.

AU - Figueiredo, Joanemile P.

AU - Cardoso, Luciana S.

AU - Jabar, Rafael L.

AU - Souza, Robson P.

AU - Wells, Martin T.

AU - Carvalho, Edgar M.

AU - Fitzgerald, Daniel W.

AU - Barnes, Kathleen C.

AU - Araújo, Maria Ilma

AU - Glesby, Marshall J.

PY - 2012/2

Y1 - 2012/2

N2 - Detailed knowledge of factors associated with resistance to Schistosoma mansoni infection in endemic areas might facilitate more effective schistosomiasis control. We conducted a cross-sectional study of persons resistant to schistosomiasis and found no association between socioeconomic status and resistance to infection. Mononuclear cells of resistant subjects produced higher levels of interleukin-5 (IL-5), IL-13 and interferon-γ upon stimulation with soluble egg antigen (SEA) compared with infected persons. When stimulated with Sm21.6 or Sm22.6, levels of IL-10 were higher in cell culture of resistant persons. Levels of IgE against soluble adult wormantigen (SWAP) and against interleukin- 4-inducing principle from S. mansoni eggs (IPSE) and levels of IgG4 against SWAP, SEA, and Sm22.6 were lower in the resistant group compared with the susceptible group. Our data suggest that socioeconomic status could not fully explain resistance to S. mansoni infection observed in the studied area. However, a mixture of Th1 and Th2 immune responses and low levels of specific IgG4 against parasite antigens could be mediating resistance to infection.

AB - Detailed knowledge of factors associated with resistance to Schistosoma mansoni infection in endemic areas might facilitate more effective schistosomiasis control. We conducted a cross-sectional study of persons resistant to schistosomiasis and found no association between socioeconomic status and resistance to infection. Mononuclear cells of resistant subjects produced higher levels of interleukin-5 (IL-5), IL-13 and interferon-γ upon stimulation with soluble egg antigen (SEA) compared with infected persons. When stimulated with Sm21.6 or Sm22.6, levels of IL-10 were higher in cell culture of resistant persons. Levels of IgE against soluble adult wormantigen (SWAP) and against interleukin- 4-inducing principle from S. mansoni eggs (IPSE) and levels of IgG4 against SWAP, SEA, and Sm22.6 were lower in the resistant group compared with the susceptible group. Our data suggest that socioeconomic status could not fully explain resistance to S. mansoni infection observed in the studied area. However, a mixture of Th1 and Th2 immune responses and low levels of specific IgG4 against parasite antigens could be mediating resistance to infection.

UR - http://www.scopus.com/inward/record.url?scp=84857023982&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857023982&partnerID=8YFLogxK

U2 - 10.4269/ajtmh.2012.11-0204

DO - 10.4269/ajtmh.2012.11-0204

M3 - Article

C2 - 22302866

AN - SCOPUS:84857023982

SN - 0002-9637

VL - 86

SP - 296

EP - 305

JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

IS - 2

ER -

Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this