Factors associated with pharyngoesophageal stricture in patients treated with concurrent chemotherapy and radiation therapy for oropharyngeal squamous cell carcinoma

Simon R. Best; Patrick K. Ha; Ray G. Blanco; John R. Saunders; Eva S. Zinreich; Marshall A. Levine; Sara I. Pai; Melissa Walker; Jaclyn Trachta; Karen Ulmer; Peter Murakami; Richard Thompson; Joseph A. Califano; Barbara P. Messing

doi:10.1002/hed.21657

Factors associated with pharyngoesophageal stricture in patients treated with concurrent chemotherapy and radiation therapy for oropharyngeal squamous cell carcinoma

Simon R. Best, Patrick K. Ha, Ray G. Blanco, John R. Saunders, Eva S. Zinreich, Marshall A. Levine, Sara I. Pai, Melissa Walker, Jaclyn Trachta, Karen Ulmer, Peter Murakami, Richard Thompson, Joseph A. Califano, Barbara P. Messing

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Background The purpose of this study was to elucidate factors associated with pharyngoesophageal strictures after treatment for head and neck squamous cell carcinoma (SCC). Methods We conducted a retrospective review of patients receiving cisplatin and 5-fluorouracil chemotherapy combined with concurrent hyperfractionated radiation therapy for oropharyngeal squamous cell carcinoma. Results Strictures developed in 13 of 67 patients (19%). Strictures were associated with tumor location (tonsil vs base of tongue; p =.03), neck dissection after completion of therapy (p =.03), and the duration of treatment-induced mucositis (weeks with mucositis grade ≥2; National Cancer Institute (NCI) Common Toxicity Criteria; p <.001). Age, sex, race, tumor stage, nodal stage, American Joint Committee on Cancer (AJCC) stage, human papillomavirus (HPV) status, smoking, radiation dose, maximum severity of mucositis, amifostine use, and pretreatment swallow dysfunction were not significantly associated with stricture. In multivariate analysis, only duration of mucositis, after controlling for age, sex, and tumor location, remained highly significant (p <.01). Conclusion The duration of treatment-related mucositis is an independent risk factor for stricture formation in patients with oropharyngeal SCC treated with concurrent chemotherapy and radiation therapy.

Original language	English (US)
Pages (from-to)	1727-1734
Number of pages	8
Journal	Head and Neck
Volume	33
Issue number	12
DOIs	https://doi.org/10.1002/hed.21657
State	Published - Dec 2011

Keywords

chemoradiation
oropharyngeal
pharyngoesophageal
squamous cell carcinoma
stricture

ASJC Scopus subject areas

Otorhinolaryngology

Access to Document

10.1002/hed.21657

Cite this

Best, S. R., Ha, P. K., Blanco, R. G., Saunders, J. R., Zinreich, E. S., Levine, M. A., Pai, S. I., Walker, M., Trachta, J., Ulmer, K., Murakami, P., Thompson, R., Califano, J. A., & Messing, B. P. (2011). Factors associated with pharyngoesophageal stricture in patients treated with concurrent chemotherapy and radiation therapy for oropharyngeal squamous cell carcinoma. Head and Neck, 33(12), 1727-1734. https://doi.org/10.1002/hed.21657

Best, SR, Ha, PK, Blanco, RG, Saunders, JR, Zinreich, ES, Levine, MA, Pai, SI, Walker, M, Trachta, J, Ulmer, K, Murakami, P, Thompson, R, Califano, JA & Messing, BP 2011, 'Factors associated with pharyngoesophageal stricture in patients treated with concurrent chemotherapy and radiation therapy for oropharyngeal squamous cell carcinoma', Head and Neck, vol. 33, no. 12, pp. 1727-1734. https://doi.org/10.1002/hed.21657

@article{6dae9fd365b1486784f3f830d4dbca91,

title = "Factors associated with pharyngoesophageal stricture in patients treated with concurrent chemotherapy and radiation therapy for oropharyngeal squamous cell carcinoma",

abstract = "Background The purpose of this study was to elucidate factors associated with pharyngoesophageal strictures after treatment for head and neck squamous cell carcinoma (SCC). Methods We conducted a retrospective review of patients receiving cisplatin and 5-fluorouracil chemotherapy combined with concurrent hyperfractionated radiation therapy for oropharyngeal squamous cell carcinoma. Results Strictures developed in 13 of 67 patients (19%). Strictures were associated with tumor location (tonsil vs base of tongue; p =.03), neck dissection after completion of therapy (p =.03), and the duration of treatment-induced mucositis (weeks with mucositis grade ≥2; National Cancer Institute (NCI) Common Toxicity Criteria; p <.001). Age, sex, race, tumor stage, nodal stage, American Joint Committee on Cancer (AJCC) stage, human papillomavirus (HPV) status, smoking, radiation dose, maximum severity of mucositis, amifostine use, and pretreatment swallow dysfunction were not significantly associated with stricture. In multivariate analysis, only duration of mucositis, after controlling for age, sex, and tumor location, remained highly significant (p <.01). Conclusion The duration of treatment-related mucositis is an independent risk factor for stricture formation in patients with oropharyngeal SCC treated with concurrent chemotherapy and radiation therapy.",

keywords = "chemoradiation, oropharyngeal, pharyngoesophageal, squamous cell carcinoma, stricture",

author = "Best, {Simon R.} and Ha, {Patrick K.} and Blanco, {Ray G.} and Saunders, {John R.} and Zinreich, {Eva S.} and Levine, {Marshall A.} and Pai, {Sara I.} and Melissa Walker and Jaclyn Trachta and Karen Ulmer and Peter Murakami and Richard Thompson and Califano, {Joseph A.} and Messing, {Barbara P.}",

year = "2011",

month = dec,

doi = "10.1002/hed.21657",

language = "English (US)",

volume = "33",

pages = "1727--1734",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "Wiley-Liss Inc.",

number = "12",

}

TY - JOUR

T1 - Factors associated with pharyngoesophageal stricture in patients treated with concurrent chemotherapy and radiation therapy for oropharyngeal squamous cell carcinoma

AU - Best, Simon R.

AU - Ha, Patrick K.

AU - Blanco, Ray G.

AU - Saunders, John R.

AU - Zinreich, Eva S.

AU - Levine, Marshall A.

AU - Pai, Sara I.

AU - Walker, Melissa

AU - Trachta, Jaclyn

AU - Ulmer, Karen

AU - Murakami, Peter

AU - Thompson, Richard

AU - Califano, Joseph A.

AU - Messing, Barbara P.

PY - 2011/12

Y1 - 2011/12

N2 - Background The purpose of this study was to elucidate factors associated with pharyngoesophageal strictures after treatment for head and neck squamous cell carcinoma (SCC). Methods We conducted a retrospective review of patients receiving cisplatin and 5-fluorouracil chemotherapy combined with concurrent hyperfractionated radiation therapy for oropharyngeal squamous cell carcinoma. Results Strictures developed in 13 of 67 patients (19%). Strictures were associated with tumor location (tonsil vs base of tongue; p =.03), neck dissection after completion of therapy (p =.03), and the duration of treatment-induced mucositis (weeks with mucositis grade ≥2; National Cancer Institute (NCI) Common Toxicity Criteria; p <.001). Age, sex, race, tumor stage, nodal stage, American Joint Committee on Cancer (AJCC) stage, human papillomavirus (HPV) status, smoking, radiation dose, maximum severity of mucositis, amifostine use, and pretreatment swallow dysfunction were not significantly associated with stricture. In multivariate analysis, only duration of mucositis, after controlling for age, sex, and tumor location, remained highly significant (p <.01). Conclusion The duration of treatment-related mucositis is an independent risk factor for stricture formation in patients with oropharyngeal SCC treated with concurrent chemotherapy and radiation therapy.

AB - Background The purpose of this study was to elucidate factors associated with pharyngoesophageal strictures after treatment for head and neck squamous cell carcinoma (SCC). Methods We conducted a retrospective review of patients receiving cisplatin and 5-fluorouracil chemotherapy combined with concurrent hyperfractionated radiation therapy for oropharyngeal squamous cell carcinoma. Results Strictures developed in 13 of 67 patients (19%). Strictures were associated with tumor location (tonsil vs base of tongue; p =.03), neck dissection after completion of therapy (p =.03), and the duration of treatment-induced mucositis (weeks with mucositis grade ≥2; National Cancer Institute (NCI) Common Toxicity Criteria; p <.001). Age, sex, race, tumor stage, nodal stage, American Joint Committee on Cancer (AJCC) stage, human papillomavirus (HPV) status, smoking, radiation dose, maximum severity of mucositis, amifostine use, and pretreatment swallow dysfunction were not significantly associated with stricture. In multivariate analysis, only duration of mucositis, after controlling for age, sex, and tumor location, remained highly significant (p <.01). Conclusion The duration of treatment-related mucositis is an independent risk factor for stricture formation in patients with oropharyngeal SCC treated with concurrent chemotherapy and radiation therapy.

KW - chemoradiation

KW - oropharyngeal

KW - pharyngoesophageal

KW - squamous cell carcinoma

KW - stricture

UR - http://www.scopus.com/inward/record.url?scp=81255149653&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=81255149653&partnerID=8YFLogxK

U2 - 10.1002/hed.21657

DO - 10.1002/hed.21657

M3 - Article

C2 - 21246640

AN - SCOPUS:81255149653

SN - 1043-3074

VL - 33

SP - 1727

EP - 1734

JO - Head and Neck

JF - Head and Neck

IS - 12

ER -

Factors associated with pharyngoesophageal stricture in patients treated with concurrent chemotherapy and radiation therapy for oropharyngeal squamous cell carcinoma

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this