TY - JOUR
T1 - Factors affecting early childhood growth in hypoxic-ischemic encephalopathy treated with hypothermia
AU - Jayakumar, Srishti
AU - Burton, Vera Joanna
AU - Perin, Jamie
AU - Asafu-Adjaye, Daniella
AU - Cristofalo, Elizabeth
AU - Northington, Frances
AU - Chavez-Valdez, Raul
AU - Leppert, Mary
AU - Allen, Marilee C
AU - Gerner, Gwendolyn
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Nature America, Inc. 2024.
PY - 2024/4
Y1 - 2024/4
N2 - Introduction: There is an extensive body of research regarding neurological outcomes following neonatal hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH), with limited data on growth outcomes. We examined perinatal characteristics associated with postnatal growth in this population. Methods: Convenience cohort of 66 infants with HIE who underwent TH and participated in follow-up at 24 months of age were included. Regression modeling including perinatal anthropomorphics, markers of HIE, and systemic injury was used to evaluate growth at 24 months. Results: Birth head circumference was associated with weight (p = 0.036). MRI severity, pH at admission and birth head circumference were associated with height (p = 0.043, p = 0.015 and p = 0.043 respectively). MRI severity and length of intubation were associated with head circumference (p = 0.038 and p < 0.001 respectively). Conclusion: There was a significant association between specific early factors and growth at 24 months among infants with HIE treated with TH.
AB - Introduction: There is an extensive body of research regarding neurological outcomes following neonatal hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH), with limited data on growth outcomes. We examined perinatal characteristics associated with postnatal growth in this population. Methods: Convenience cohort of 66 infants with HIE who underwent TH and participated in follow-up at 24 months of age were included. Regression modeling including perinatal anthropomorphics, markers of HIE, and systemic injury was used to evaluate growth at 24 months. Results: Birth head circumference was associated with weight (p = 0.036). MRI severity, pH at admission and birth head circumference were associated with height (p = 0.043, p = 0.015 and p = 0.043 respectively). MRI severity and length of intubation were associated with head circumference (p = 0.038 and p < 0.001 respectively). Conclusion: There was a significant association between specific early factors and growth at 24 months among infants with HIE treated with TH.
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U2 - 10.1038/s41372-024-01890-x
DO - 10.1038/s41372-024-01890-x
M3 - Article
C2 - 38326606
AN - SCOPUS:85184174690
SN - 0743-8346
VL - 44
SP - 532
EP - 538
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 4
ER -