Face processing of social cognition in patients with first episode psychosis: Its deficits and association with the right subcallosal anterior cingulate cortex

Zui Narita, Kun Yang, Hironori Kuga, Peeraya Piancharoen, Semra Etyemez, Andreia Faria, Marina Mihaljevic, Luisa Longo, Ho Namkung, Jennifer M. Coughlin, Gerald Nestadt, Frederik C. Nucifora, Thomas W. Sedlak, Rebecca Schaub, Jeff Crawford, David J. Schretlen, Jun Miyata, Koko Ishizuka, Akira Sawa

Research output: Contribution to journalArticlepeer-review

Abstract

The clinical importance of social cognition is well acknowledged in patients with psychosis, in particular those with first episode psychosis (FEP). Nevertheless, its brain substrates and circuitries remain elusive, lacking precise analysis between multimodal brain characteristics and behavioral sub-dimensions within social cognition. In the present study, we examined face processing of social cognition in 71 FEP patients and 77 healthy controls (HCs). We looked for a possible correlation between face processing and multimodal MRI characteristics such as resting-state functional connectivity (rsFC) and brain volume. We observed worse recognition accuracy, longer recognition response time, and longer memory response time in FEP patients when compared with HCs. Of these, memory response time was selectively correlated with specific rsFCs, which included the right subcallosal sub-region of BA24 in the ACC (scACC), only in FEP patients. The volume of this region was also correlated with memory response time in FEP patients. The scACC is functionally and structurally important in FEP-associated abnormalities of face processing measures in social cognition.

Original languageEnglish (US)
Pages (from-to)99-107
Number of pages9
JournalSchizophrenia Research
Volume238
DOIs
StatePublished - Dec 2021

Keywords

  • Anterior cingulate cortex
  • BA24
  • Emotional processing
  • MRI
  • Psychosis

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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