TY - JOUR
T1 - Face processing of social cognition in patients with first episode psychosis
T2 - Its deficits and association with the right subcallosal anterior cingulate cortex
AU - Narita, Zui
AU - Yang, Kun
AU - Kuga, Hironori
AU - Piancharoen, Peeraya
AU - Etyemez, Semra
AU - Faria, Andreia
AU - Mihaljevic, Marina
AU - Longo, Luisa
AU - Namkung, Ho
AU - Coughlin, Jennifer M.
AU - Nestadt, Gerald
AU - Nucifora, Frederik C.
AU - Sedlak, Thomas W.
AU - Schaub, Rebecca
AU - Crawford, Jeff
AU - Schretlen, David J.
AU - Miyata, Jun
AU - Ishizuka, Koko
AU - Sawa, Akira
N1 - Funding Information:
This work was supported by the National Institutes of Health (MH-094268, Silvio O. Conte Center, MH-092443, MH-105660, and MH-107730) to A.S. and S&R/RUSK, Stanley foundation. The Mitsubishi Tanabe Pharma Corporation supported a portion of the study participant recruitment cost. The authors wish to extend their gratitude to the participants in the current study. We appreciate Dr. Melissa A. Landek-Salgado for critical reading of this manuscript. We thank the study participant recruitment team led by Ms. Yukiko Lema. We also wish to thank Dr. Takanori Ogaru for their assistance in implementing the research.
Funding Information:
This work was supported by the National Institutes of Health ( MH-094268 , Silvio O. Conte Center, MH-092443 , MH-105660 , and MH-107730 ) to A.S., and S&R/RUSK, Stanley foundation. The Mitsubishi Tanabe Pharma Corporation supported a portion of the study participant recruitment cost.
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/12
Y1 - 2021/12
N2 - The clinical importance of social cognition is well acknowledged in patients with psychosis, in particular those with first episode psychosis (FEP). Nevertheless, its brain substrates and circuitries remain elusive, lacking precise analysis between multimodal brain characteristics and behavioral sub-dimensions within social cognition. In the present study, we examined face processing of social cognition in 71 FEP patients and 77 healthy controls (HCs). We looked for a possible correlation between face processing and multimodal MRI characteristics such as resting-state functional connectivity (rsFC) and brain volume. We observed worse recognition accuracy, longer recognition response time, and longer memory response time in FEP patients when compared with HCs. Of these, memory response time was selectively correlated with specific rsFCs, which included the right subcallosal sub-region of BA24 in the ACC (scACC), only in FEP patients. The volume of this region was also correlated with memory response time in FEP patients. The scACC is functionally and structurally important in FEP-associated abnormalities of face processing measures in social cognition.
AB - The clinical importance of social cognition is well acknowledged in patients with psychosis, in particular those with first episode psychosis (FEP). Nevertheless, its brain substrates and circuitries remain elusive, lacking precise analysis between multimodal brain characteristics and behavioral sub-dimensions within social cognition. In the present study, we examined face processing of social cognition in 71 FEP patients and 77 healthy controls (HCs). We looked for a possible correlation between face processing and multimodal MRI characteristics such as resting-state functional connectivity (rsFC) and brain volume. We observed worse recognition accuracy, longer recognition response time, and longer memory response time in FEP patients when compared with HCs. Of these, memory response time was selectively correlated with specific rsFCs, which included the right subcallosal sub-region of BA24 in the ACC (scACC), only in FEP patients. The volume of this region was also correlated with memory response time in FEP patients. The scACC is functionally and structurally important in FEP-associated abnormalities of face processing measures in social cognition.
KW - Anterior cingulate cortex
KW - BA24
KW - Emotional processing
KW - MRI
KW - Psychosis
UR - http://www.scopus.com/inward/record.url?scp=85116859065&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85116859065&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2021.09.027
DO - 10.1016/j.schres.2021.09.027
M3 - Article
C2 - 34649085
AN - SCOPUS:85116859065
SN - 0920-9964
VL - 238
SP - 99
EP - 107
JO - Schizophrenia Research
JF - Schizophrenia Research
ER -